Journal of Psychopharmacology
December 17, 2022
Miriam Marguilho, Inês Figueiredo, Pedro Castro-Rodrigues
57 citations
Ketamine is an N-methyl-d-aspartate antagonist which is increasingly being researched and used as a treatment for depression. In low doses, it can cause a transitory modification in consciousness which was classically labelled as ‘dissociation’. However, ketamine is also commonly classified as an atypical psychedelic and it has been recently reported that ego dissolution experiences during...
bioRxiv (Cold Spring Harbor Laboratory)
December 11, 2022
Benjamin J. B. Bréant, José Prius-Mengual, David M. Bannerman et al.
5 citations
preprint
Abstract Psychedelics lead to profound changes in subjective experience and behaviour, which are typically conceptualised in psychological terms rather than corresponding to an altered brain state or a distinct state of arousal. Here, we performed chronic electrophysiological recordings from the cortex concomitant with pupillometry in freely moving adult male mice following an injection of a...
Neurosurgery
December 8, 2022
Akanksha Sharma, Shanthi Gowrinathan, Karina Sergi et al.
13 citations
After a decades-long pause, psychedelics are again being intensely investigated for treating a wide range of neuropsychiatric ailments including depression, anxiety, addiction, post-traumatic stress disorder, anorexia, and chronic pain syndromes. The classic serotonergic psychedelics psilocybin and lysergic acid diethylamide and nonclassic psychedelics 3,4-methylenedioxymethamphetamine and...
Molecular Pharmacology
December 2022
Taryn Bosquez-Berger, Sierra Wilson, Christos Iliopoulos-Tsoutsouvas et al.
The two main constituents of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). While Δ9-THC pharmacology has been studied extensively, CBD-long considered inactive-is now the subject of vigorous research related to epilepsy, pain, and inflammation and is popularly embraced as a virtual cure-all. However, our understanding of CBD pharmacology remains limited, although CBD...
International Journal of Molecular Sciences
November 23, 2022
Alina Wilkowska, Wiesław Jerzy Cubała
17 citations
Treatment-resistant depression is a pleomorphic phenomenon occurring in 30% of patients with depression. The chance to achieve remission decreases with every subsequent episode. It constitutes a significant part of the global disease burden, causes increased morbidity and mortality, and is associated with poor quality of life. It involves multiple difficult-to-treat episodes, with increasing...
Psychoactives
November 21, 2022
Rafael G. Dos Santos, Jaime E. C. Hallak
In the last two decades, an increasing trend has unfolded toward the possible beneficial uses of natural hallucinogenic substances for treating mental health disorders [...]
Neuropharmacology
November 17, 2022
Satoshi Deyama, Katsuyuki Kaneda
The neurotrophic hypothesis of depression proposes that reduced levels of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) contribute to neuronal atrophy or loss in the prefrontal cortex (PFC) and hippocampus and impaired hippocampal adult neurogenesis, which are associated with depressive symptoms. Chronic, but acute, treatment with typical monoaminergic...
C&EN Global Enterprise
November 7, 2022
Gina Vitale
Lusaris Therapeutics has launched with $60 million in series A financing to develop therapies for severe neuropsychiatric and neurological conditions. The start-up says the type of compounds it is developing, serotonergic neuroplastogens, are able to induce favorable neural plasticity. Its lead candidate, for treatment-resistant depression, is a formulation of the psychedelic 5-Methoxy- N , N...
Biomolecules
November 2, 2022
Giordano Novak Rossi, Lorena T. L. Guerra, Glen B. Baker et al.
29 citations
Ayahuasca is a psychoactive brew traditionally used in indigenous and religious rituals and ceremonies in South America for its therapeutic, psychedelic, and entheogenic effects. It is usually prepared by lengthy boiling of the leaves of the bush Psychotria viridis and the mashed stalks of the vine Banisteriopsis caapi in water. The former contains the classical psychedelic...
Korean Journal of Christian Studies
October 31, 2022
Hyoju Lee
신경과학(neuroscience) 분야는 미국 대통령 조지 부시(George H. W. Bush)가 1990~1999년을 “뇌의 십년”(the decade of the brain)으로 선포한 후 눈부신 발전을 이루었다. 계속되는 기술의 발전은 인간의 뇌에 대한 새로운 이해의 지평을 여는 데 큰 기여를 했다. 신경과학이 발전하면서 의학계와 심리학계 등 다양한 분야의 전문가들은 영성이 건강에 미치는 영향에 관심을 보이며 관상적 실천들이 삶의 질을 높이는 데 효과가 있음이 연구 결과로 나오고 있다. 하지만, 한국 개신교 내에서 관상적 실천이란 아직 생소하게 받아들여지는 개념이기도 하며, 침묵기도에 대한 오해가 만연하여 관상적 실천을 소개하는 데 어려움이 있다. 개신교 내에서 침묵기도의 기독교적 뿌리와 그...