Neuropharmacology
2026
Luisa Prochazkova, Laura C. Carvalho, Natasza Marrouch et al.
While microdosing psychedelics is increasingly popular for enhancing well-being, its effects on health behavior change (HBC) remain poorly understood. This study investigated self-reported health-related behavior changes and putative underlying psychological mechanisms associated with psychedelic microdosing in a naturalistic setting. A retrospective mixed-method survey was conducted with 365...
Neuropharmacology
November 2, 2025
Luisa Prochazkova, Josephine Marschall, Michiel van Elk et al.
2 citations
BackgroundTaking very small doses of psychedelics (LSD, truffles) over an extended period became prevalent in Western societies for its alleged cognitive benefit, including enhanced creativity. However, in the absence of robust, double-blind-controlled quantitative studies, such claims remain anecdotal.MethodsHere we present results from 3 double-blind placebo-controlled longitudinal trials...
Neuropharmacology
October 17, 2025
Luisa Prochazkova, Josephine Marschall, Dominique P. Lippelt et al.
3 citations
ObjectiveMicrodosing psychedelics has been widely reported to enhance focus and problem-solving, sparking interest in its potential to treat attentional disorders such as ADHD. However, existing studies largely rely on anecdotal evidence and lack adequate placebo control.MethodsThis study contributes to the literature by examining the longitudinal effects of microdosing psilocybin truffles in...
Journal of Psychopharmacology
December 17, 2021
Josephine Marschall, George Fejer, Pascal Lempe et al.
69 citations
Background: Microdoses of psychedelics (i.e. a sub-hallucinogenic dose taken every third day) can reduce symptoms of depression, anxiety and stress according to anecdotal reports and observational studies. Research with medium to high doses of psilocybin points towards potential underlying mechanisms, including the modulation of emotion and interoceptive processing. Aims: In this preregistered...
June 14, 2021
Luisa Prochazkova, Michiel van Elk, Josephine Marschall et al.
4 citations
preprint
Introduction: Microdosing refers to the repetitive administration of tiny doses of psychedelics (LSD, Psilocybin) over an extended period of time. This practice has been linked to alleged cognitive benefits, such as improved mood and creativity, potentiated by targeting serotonergic 5-HT2A receptors and facilitating cognitive flexibility. Nonetheless, in the absence of robust, quantitative and...
2020
Luisa Prochazkova, Bernhard Hommel
Abstract Increasing evidence suggests that altered states of consciousness (ASC) are associated with both positive and negative effects on components of creative performance, and convergent and divergent thinking in particular. We provide a metacontrol framework that allows characterizing factors that induce ASC in terms of their general impact on the information processing style of problem...
Psychopharmacology
October 24, 2018
Luisa Prochazkova, Dominique P. Lippelt, Lorenza S. Colzato et al.
181 citations
While this study provides quantitative support for the cognitive-enhancing properties of microdosing psychedelics, future research has to confirm these preliminary findings in more rigorous placebo-controlled study designs. Based on these preliminary results, we speculate that psychedelics might affect cognitive metacontrol policies by optimizing the balance between cognitive persistence and...