Introduction: [68Ga]Ga-DO3A-VS-Cys40-Tuna-2 (previously published as [68Ga]Ga-DO3A-VS-Cys40-S01-GCG) has shown high-affinity specific binding to the glucagon receptor (GCGR) in vitro and in vivo in rats and non-human primates in our previous studies, confirming the suitability of the tracer for drug development applications in humans. The manufacturing process of [68Ga]Ga-DO3A-VS-Cys40-Tuna-2...
99mTc-PHC-102 is a 99mTc-labeled derivative of acetazolamide, a high-affinity small organic ligand of carbonic anhydrase IX (CAIX). 99mTc-PHC-102 has previously shown favorable in vivo biodistribution properties in mouse models of CAIX-positive clear cell renal cell carcinoma (ccRCC) and colorectal cancer. In this study, we aimed to explore the targeting performance of 99mTc-PHC-102 in SPECT in...
Abstract: Fertilizer microdosing (FM) is being promoted in sub‐Saharan Africa (SSA) to boost crop productivity on smallholder farms. However, yield response variability is a barrier to adoption. We conducted a meta‐analysis to analyze the variability in cereal crop yield response to FM and to determine the main factors associated with this variability. Thirty publications pertaining to millet...
Background: The use of psychedelic substances like LSD and magic mushrooms in research and to treat mental health conditions has been increasing in the last decade. In particular, the practice of microdosing – using sub-hallucinogenic amounts of psychedelics – has been increasing (Anderson et al., 2019), but large-scale systemic qualitative analyses are still scant.Aims: This study attempted to...
The regular consumption of very small doses of psychedelic drugs (known as microdosing) has been a source of growing media and community attention in recent years. However, there is currently limited clinical and social research evidence on the potential role of microdosing as therapies for mental and substance use disorders. This paper examined subjective experiences of microdosing...
AgronomyApril 29, 2020Abdourahamane Issa M. Nourou, Addam Kiari Saidou, Warouma Arifa et al.
Pearl millet production in Niger is characterized by manual sowing and weeding and low use of inputs like mineral and organic fertilizer. This objective of the study was to compare a traditional production package (control) against a new production package consisting of mechanized sowing and weeding, seed priming, seed treatment with a fungicide/insecticide, and microdosing at rate of 0.3 g NPK...
Research shows that due to rapidly changing higher education contexts, large numbers of academics are overworked, stressed, and dispirited. This is exacerbated by the fact that most academics do not view academia simply as work, but as a vocation. To deal with these conditions, the use of cognitive modification and enhancement drugs have become far more prevalent than used to be the case. In...
Rationale: Microdosing psychedelics – the practice of consuming small, sub-hallucinogenic doses of substances such as LSD or psilocybin – is gaining attention in popular media but remains poorly characterized. Contemporary studies of psychedelic microdosing have yet to report the basic psychiatric descriptors of psychedelic microdosers. Objectives: To examine the practices and demographics of a...
Anecdotal reports suggest that the administration of sub-hallucinogenic doses of psychedelic compounds on a chronic, intermittent schedule – a practice known as psychedelic microdosing – is becoming increasingly popular among young adults due to its purported ability to reduce symptoms of depression and anxiety while improving cognitive function and promoting social interaction. Using an...
Abstract Background The requirement for moderate withdrawal prior to initiation can be a barrier to buprenorphine/naloxone induction. Case presentation We aimed to use a microdosing regimen to initiate regular dosing of buprenorphine/naloxone in a high-risk patient with a history of failed initiations due, in part, to withdrawal symptoms. Using an assertive outreach model and a...