Journal of opioid management
2021
Arjun Tara, Gregory Acampora, Jingping Wang et al.
We report a case in which sublingual buprenorphine was used to help transition a patient off intravenous (IV) opioid analgesics medications post-multiple abdominal procedures. Intravenous opioids are commonly used in inpatient surgical pain management for patients with severe pain who are unable to take oral medications. Typically, a short course of IV analgesics is used, followed by transition...
Journal of opioid management
2021
René C Vytialingam, Stephan A Schug, Richard O'Regan
Buprenorphine/naloxone (BPN/NX) is a first-line treatment for opioid use disorder. Conventional treatment guidelines recommend a period of opioid abstinence and the presence of moderate withdrawal before initiation to avoid precipitated withdrawal. A newer approach of "microdosing" removes this requirement and has potential benefits. We present two cases of successful induction of BPN/NX using...
December 11, 2020
Balázs Szigeti, Laura Kärtner, Allan Blemings et al.
1 citation
Psychedelic psychotherapy, therapy enhanced with psychedelic drugs such as LSD or psilocybin (the active ingredient of ‘magic mushrooms’), has been suggested to improve psychological well-being. For this reason, trials on psychedelic therapy for the treatment of depression, addiction and other conditions are ongoing. Recently, ‘microdosing’ – a way of administering psychedelics that involves...
Frontiers in Sustainable Food Systems
December 8, 2020
Abdourahamane Issa M. Nourou, Addam Kiari Saidou, Jens B. Aune
The objective of this study was to characterize pearl millet production in Niger and to assess the potential impact of a low-cost production package on land- and labor productivity. The survey showed that 62% of the farmers used manure, while 22% used mineral fertilizer. Of those who used mineral fertilizer only 18% practiced microdosing. High labor demand was given as the reason why 89% of the...
Transplantation Direct
October 26, 2020
Hari V. Kalluri, Puneet Sood, Wenchen Zhao et al.
Background. Renal transplantation is the treatment of choice for patients with end-stage renal disease. Because kidneys are the primary excretory organs for various drugs/drug metabolites, changes in renal graft function would significantly alter the clearance and exposure of renally secreted drugs. Renal allografts from living and deceased donors normally undergo numerous insults, including...
Journal of the American College of Emergency Physicians Open
October 20, 2020
J. Moe, K. Badke, Megan Pratt et al.
Emergency department (ED)–initiated buprenorphine may prevent overdose. Microdosing is a novel approach that does not require withdrawal, which can be a barrier to standard inductions. We aimed to evaluate the feasibility of an ED‐initiated buprenorphine/naloxone program providing standard‐dosing and microdosing take‐home packages and of randomizing patients to either intervention.
Journal of Psychopharmacology
October 8, 2020
Rotem Petranker, Thomas Anderson, Larissa J. Maier et al.
57 citations
Background: Microdosing psychedelics is the practice of taking small, sub-hallucinogenic doses of lysergic acid diethylamide or psilocybin-containing mushrooms. Despite its surging popularity, little is known about the specific intentions to start microdosing and the effects of this practice. Aims: First, we aimed to replicate previous findings regarding the subjective benefits and challenges...
Neuroscience & Biobehavioral Reviews
October 5, 2020
Genís Ona, José Carlos Bouso
59 citations
Microdosing psychedelic drugs-that is, taking sub-behavioral doses of lysergic acid diethylamide (LSD) or psilocybin-is a growing practice in Western societies. Taken mainly for creative or mood-enhancing purposes, thousands of users are increasingly being exposed to (micro)doses of psychedelic drugs. In this systematic review, we searched the available evidence from human studies, focusing our...
A&A Practice
September 21, 2020
Isaiah T. Crum, VaKara M. Meyer Karre, Alëna A. Balasanova
A 76-year-old woman with chronic noncancer pain and an intrathecal hydromorphone–bupivacaine pump was admitted for acute exacerbation of heart failure. Her pump was unable to be replaced due to medical comorbidities. She was unable to tolerate oral opioids due to ventilatory depression. Tapering hydromorphone resulted in opioid withdrawal due to physiological dependence. Microdosing of...
Nature Reviews Drug Discovery
September 8, 2020
Tal Burt, Graeme C. Young, Wooin Lee et al.
101 citations
Phase 0 approaches - which include microdosing - evaluate subtherapeutic exposures of new drugs in first-in-human studies known as exploratory clinical trials. Recent progress extends phase 0 benefits beyond assessment of pharmacokinetics to include understanding of mechanism of action and pharmacodynamics. Phase 0 approaches have the potential to improve preclinical candidate selection and...