Neuroscience
January 23, 2009
E Alves, Z Binienda, F Carvalho et al.
3,4-Methylenedioximethamphetamine (MDMA, ecstasy) is a worldwide abused stimulant drug, with persistent neurotoxic effects and high prevalence among adolescents. The massive release of 5-HT from pre-synaptic storage vesicles induced by MDMA followed by monoamine oxidase B (MAO-B) metabolism, significantly increases oxidative stress at the mitochondrial level. l-Carnitine and its ester,...
Addiction and Health
2009
A. Nakhaee, Amirhossein Ghassemi, Zahra Torshizi et al.
Background: Psychedelic drugs can cause one to get out of normal status and permanent cerebral defects, via affecting central nervous system. Consumption of theses drugs seems to be increasing nowadays especially among the youth and university educated population. We conducted a study to evaluate the awareness of medical science students of Kerman University of medical science who are going to...
Health and History
2009
Mathew T Martin-Iverson
Health& History 1112 2009 159 has to sort through a lot of other stuff to get it.He has some trouble keeping onmessage, often diverting tonon-related areas of psychiatric history. Then, we have to deal with his well-known opinions of the dreaded drug companies who are undoubtedly a part of the history, but could have been dealt with more objectively. I rather enjoyed his interludes into the...
Diseño interior
2009
Pilar Gómez Rodríguez
632 citations
Randomized clinical trials support the efficacy of MDMA in the treatment of PTSD and psilocybin in the treatment of depression and cancer-related anxiety. The research to support the use of LSD and ayahuasca in the treatment of psychiatric disorders is preliminary, although promising. Overall, the database is insufficient for FDA approval of any psychedelic compound for routine clinical use in...
Journal of Neuroimmune Pharmacology
December 2008
Bryan K. Yamamoto, Jamie Raudensky
Methamphetamine (METH) and 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are amphetamine derivatives with high abuse liability. These amphetamine-related drugs of abuse mediate their effects through the acute activation of both dopaminergic and serotonergic neurons. Long-term abuse of these amphetamine derivatives, however, results in damage to both dopaminergic and serotonergic terminals...
Yakugaku Zasshi
October 1, 2008
Nahoko Uchiyama, Ruri Kikura-Hanajiri, Nobuo Kawahara et al.
46 citations
Many psychotropic substances are easily available in Japan via the Internet, thus the spread of drug abuse is becoming more serious problem. To avoid drug abuse, 32 substances have been controlled in Japan since April in 2007 by the Pharmaceutical Affairs Law as designated substances (Shitei-Yakubutsu, classified as 11 tryptamines, 11 phenethylamines, 2 piperazines, 6 alkyl nitrites, 1...
Addiction Biology
September 2008
Jenny L Wiley, Rhys L Evans, Darren B Grainger et al.
Lifelong substance abuse is often initiated during adolescence; yet, most pre-clinical research in this area has been conducted in adult animals. Substantial evidence exists that the brain development that continues throughout adolescence may result in pharmacological responses that differ in a crucial manner from those of adults. The goal of this study was to evaluate age differences in motor...
Human Psychopharmacology: Clinical and Experimental
August 1, 2008
Nicholas T. van Dam, Mitch Earleywine, Greg DiGiacomo
AbstractObjectiveTo examine psychosis‐like symptoms in users of legal and illicit drugs.MethodsSchizotypal Personality Questionnaire (SPQ) scores were compared in groups of people with different exposure to cannabis, with the use of other drugs serving as a covariate. Supplemental analyses compared users of legal and illicit drugs with cannabis use as a covariate.ResultsWeekly (n = 111) and...
Behavioural Pharmacology
July 2008
Matthew L Banks, Robert W Gould, Paul W Czoty et al.
Concurrent schedules of reinforcement are increasingly being used to investigate the reinforcing strength of abused drugs. A purported advantage of concurrent schedules is that the primary dependent measure, percentage of responses emitted on the drug-associated manipulandum, is independent of the rate-altering effects of drugs. Data supporting this hypothesis are, however, rarely presented,...
Neuropharmacology
June 2008
C Chipana, I Torres, J Camarasa et al.
We hypothesize that 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH) interact with alpha-7 nicotinic receptors (nAChR). Here we examine whether memantine (MEM), an antagonist of NMDAR and alpha-7 nAChR, prevents MDMA and METH neurotoxicity. MEM prevented both serotonergic injury induced by MDMA in rat and dopaminergic lesion by METH in mice. MEM has a better protective effect...