Neuropsychopharmacology
June 2018
Arnauld Belmer, Emily Quentin, Silvina L Diaz et al.
Serotonin is a neurotransmitter involved in many psychiatric diseases. In humans, a lack of 5-HT2B receptors is associated with serotonin-dependent phenotypes, including impulsivity and suicidality. A lack of 5-HT2B receptors in mice eliminates the effects of molecules that directly target serotonergic neurons including amphetamine derivative serotonin releasers, and selective serotonin...
Psychopharmacology
May 31, 2018
Kim P. C. Kuypers, E. B. de Sousa Fernandes Perna, Patrick C. Dolder et al.
14 citations
BACKGROUND: New psychoactive substances (NPS) are chemical analogues designed to mimic the effects of various classic recreational drugs of abuse including MDMA, LSD, and cannabis. NPS use is associated with concern about the acute and longer-term effects particular substances might have, with abuse and addiction as potential consequences. Impulsivity and sensitivity to the rewarding effects of...
Oxford Scholarship Online
May 24, 2018
Christopher Partridge
This chapter introduces the book’s core ideas and some of the principal issues raised. Beginning with a discussion of Michel Foucault’s understanding of “technologies of the self,” it explores how drugs might be understood as “technologies of transcendence”—technologies that have the power to subvert dominant readings of reality. As such, they are always countercultural. By inducing the...
Neuropharmacology
May 15, 2018
Dino Luethi, Karolina E. Kolaczynska, Luca Docci et al.
Mephedrone is a synthetic cathinone and one of the most popular recreationally used new psychoactive substances. The aim of the present study was to characterize the in vitro pharmacology of novel analogs of mephedrone and related newly emerged designer stimulants. We determined norepinephrine, dopamine, and serotonin transporter inhibition potencies and monoamine release in...
Neuropharmacology
May 15, 2018
Laurent Karila, Geneviève Lafaye, Amandine Scocard et al.
The new psychoactive substances phenomenon continues to represent a considerable public health challenge. Synthetic cathinones are β-keto amphetamine analogues, also known as legal highs, research chemicals, bath salts. These drugs have surfaced as a popular alternative to other illicit drugs of abuse, such as cocaine, MDMA, and methamphetamine, due to their potent psychostimulant and...
International Journal of Theology, Philosophy and Science
May 12, 2018
Alexandru-Corneliu Arion
1 citation
Mysticism is about knowing and unifying man with God (unio mystica), in a process that involves concerted cognitive and ascetic efforts. Mysticism does not follow, according to the classic pattern, the moralizing of man, but reach at the direct and immediate knowledge of God. Thus, mysticism is not, firstly, a matter of ethics, but a theoretical or, rather, an epistemological one. For what is...
Philosophy Study
April 28, 2018
Marc Jean-Bernard
The philosophical horizon of this essay is theoretically comparative and hermeneutically dialogic. Its main philosophical and theological tonality expresses, in first person and through three discursive moments, the differentiated fusion of horizons between phenomenological and grammatical description and understanding of experience. After a philosophical overture—outlining the éthos of the...
Psychotropes
April 23, 2018
Christian Sueur
3 citations
L’utilisation thérapeutique des substances psychédéliques a été concomitante de la découverte du LSD et de la Mescaline après la Seconde Guerre mondiale. Ces utilisations thérapeutiques concernaient, à l’origine, essentiellement « l’accompagnement » des psychothérapies (thérapies psycholytiques), le traitement des addictions (alcool, puis opiacés) et, du fait de leurs capacités anxiolytiques et...
Drug Testing and Analysis
April 19, 2018
Gavin McLaughlin, Michael H. Baumann, Pierce V. Kavanagh et al.
8 citations
The availability of new psychoactive substances (NPS) on the recreational drug market continues to create challenges for scientists in the forensic, clinical and toxicology fields. Phenmetrazine (3-methyl-2-phenylmorpholine) and an array of its analogs form a class of psychostimulants that are well documented in the patent and scientific literature. The present study reports on two...
Inner Sound
April 12, 2018
Jonathan Weinel
Abstract: This chapter explores how sound systems place electronic sounds in a social context, eliciting powerful affective experiences that are framed by conceptual meaning. The chapter begins by tracing the origins of the sound system culture and dub-reggae of Jamaica. This approach, which prioritizes DJ performances over ‘live’ musicians, would prefigure the electronic dance music culture of...