The Senior Care Pharmacist
July 31, 2024
Leigh Davitian
1 citation
In recent years, scientists have initiated a renaissance in psychedelic research following decades of prohibition. Compounds such as ketamine, LSD, and psilocybin 'once primarily associated with recreational use' are now being investigated for their therapeutic potential, with promising results. An estimated 40-60% of people with post-traumatic stress disorder (PTSD) do not respond to selective...
Journal of Psychopharmacology
July 28, 2024
Kurt Stocker, Matthias E. Liechti
15 citations
Science on methylenedioxymethamphetamine (MDMA) and MDMA-like substances is faced with the unique situation that this class of psychoactive agents is referred to with two basic names for its effects on the mind: empathogens and entactogens. Empathogen usually refers to the prosocial, empathetic, and openness properties of MDMA, while entactogen usually refers to the introspective and...
Journal of Psychedelic Studies
July 18, 2024
Alex P. Hood, Chris E. Corlett, Cameron T Alldredge et al.
1 citation
AbstractBackground and AimsPost-Traumatic Stress Disorder (PTSD) is a debilitating condition that affects a sizable proportion of U.S. civilians, military personnel, and veterans. 3,4-Methylenedioxymethamphetamine-Assisted Therapy (MDMA-AT) is a novel treatment approach for PTSD that has both stirred media enthusiasm and drawn criticism. This critical review analyzes individual randomized,...
Cureus
July 1, 2024
Sabastain F Forsah, Bibi Razak, Divine Besong Arrey Agbor et al.
Ecstasy (3,4-methylenedioxymethyl-amphetamine, MDMA) is an illicit drug that has found widespread use. It is mostly used by adolescents and young adults, particularly during intense and prolonged dance parties for its mood-enhancing properties. Despite these pleasurable effects, users may have potentially serious side effects including death. One of the serious side effects is rhabdomyolysis,...
Pharmaceuticals
June 27, 2024
Haron Avgana, Roni Shira Toledano, Irit Akirav
8 citations
MDMA-assisted psychotherapy has shown potential as an effective treatment for post-traumatic stress disorder (PTSD). Preclinical studies involving rodents have demonstrated that MDMA can facilitate the extinction of fear memories. It has been noted that MDMA impacts oxytocin neurons and pro-inflammatory cytokines. Thus, the aim of this study was to explore the role of oxytocinergic signaling...
Scientific Reports
June 26, 2024
Lukas A Basedow, Tomislav Majić, Nicklas Jakob Hafiz et al.
13 citations
Classic psychedelics and MDMA have a colorful history of recreational use, and both have recently been re-evaluated as tools for the treatment of psychiatric disorders. Several studies have been carried out to assess potential long-term effects of a regular use on cognition, delivering distinct results for psychedelics and MDMA. However, to date knowledge is scarce on cognitive performance...
Scientific Reports
June 24, 2024
Srishti Rana, Jeremy R Canfield, Christopher S Ward et al.
5 citations
Hyperthermia induced by phenethylamines, such as 3,4-methylenedioxymethamphetamine (MDMA), can lead to life-threatening complications and death. Activation of the sympathetic nervous system and subsequent release of norepinephrine and activation of uncoupling proteins have been demonstrated to be the key mediators of phenethylamine-induced hyperthermia (PIH). Recently, the gut microbiome was...
Mental Health Weekly
June 14, 2024
Valerie A. Canady
A recent decision by the U.S. Food and Drug Administration's (FDA) advisory committee to reject psychedelic treatment and therapy to treat post‐traumatic stress disorder (PTSD), citing that the available evidence of midomafetamine, better known as MDMA, fails to show that the drug is effective, has been met with mixed reaction by a member of the field and an advocacy organization committed to...
Journal of Analytical Toxicology
June 11, 2024
Gunhild Heide, Ragnhild Elén Gjulem Jamt, Jonas Fainberg-Sandbu et al.
8 citations
The general use of cocaine is increasing in recent years, while the trend for 3,4-methylenedioxymethamphetamine (MDMA) is less clear. The relationship between blood concentrations and impairment is poorly understood, which complicates interpretation. The aims of this study were to report prevalence and blood concentrations of cocaine and MDMA in drugged drivers, and to investigate the...
Journal of Community Pharmacy Practice
June 10, 2024
Amit Prasad Rath
MDMA, commonly known as ecstasy or molly, is a synthetic psychoactive drug with a complex history. It produces feelings of increased empathy, emotional connection, and heightened sensory perception. While recreational use of MDMA has been prevalent, recent research suggests significant therapeutic potential in treating mental health conditions like post-traumatic stress disorder (PTSD). This...