BackgroundPsychedelic compounds such as lysergic acid diethylamide (LSD), psilocybin, and 3,4-Methylenedioxymethamphetamine (MDMA) share a long and complex history with psychiatry. A half century ago, psychedelics were widely employed by psychiatrists in investigational and clinical settings, with studies demonstrating promising findings for their use in the treatment of mental illness and...
Psychostimulants are used therapeutically and for illegal recreational purposes. Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). According to their physicochemical properties, some might also be substrates of polyspecific organic cation transporters (OCTs) that mediate uptake in liver and kidneys for metabolism and...
Objetivos: El trastorno por déficit de atención e hiperactividad es uno de los trastornos más diagnosticados en niños, adolescentes y adultos jóvenes. El mecanismo de acción de los fármacos utilizados para combatir sus síntomas se basa en la inhibición de la recaptación de neurotransmisores como la dopamina o la norepinefrina. Por otra parte, es sabido que el consumo de MDMA o éxtasis es...
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment. Unfortunately, no gold-standard treatments exist to alleviate the core socio-behavioural impairments of ASD. Meanwhile, the prosocial empathogen/entactogen 3,4-methylene-dioxy-methamphetamine (MDMA) is known to enhance...
Twenty-two participants who identified as heterosexual, lesbian, gay, bisexual or transgendered clergy of the Church of England were recruited and interviewed using a semi-structured interview. The methodology employed incorporated Transpersonal Awareness with an Interpretative Phenomenological Analysis. After several levels of analysis the following superordinate themes emerged: (a) twenty of...
Przedmiotem pracy uczyniono problematykę leczenia PTSD z wykorzystaniem MDMA jako sposobu przeciwdziałania zjawisku samobójstwa. Rozważania w tym zakresie przeprowadzono na tle polskiego prawa. W pracy wykorzystano metodę dogmatycznoprawną. Zdecydowano się przy tym skorzystać z derywacyjnej koncepcji wykładni prawa autorstwa M. Zielińskiego. Autor pracy ustalił, że: 1) PTSD może stanowić źródło...
ABSTRACT Background: Adolescent patients with a substance use disorder (SUD) often fulfil the criteria for a co-occurring post-traumatic stress disorder (PTSD). However, it is not clear if these dual-diagnosed adolescents present with unique levels of substance use and how their substance use relates to PTSD symptom clusters. Objective: To investigate substance use in adolescents with...
1. Objetivos: MDMA (3,4-metilendioximetanfetamina), comúnmente conocida como “éxtasis”, es una droga habitualmente usada en ambiente lúdico. Sus efectos tóxicos a nivel del SNC son ampliamente conocidos, habiéndose demostrado particularmente el daño que se produce sobre el sistema serotoninérgico. Como consecuencia de esta toxicidad se ha reportado la aparición de psicopatología diversa, tanto...
Stimulant and psychedelic drugs of abuse exert their effects through interactions with monoaminergic systems. Compared to other monoaminergic receptors and transporters, the 5-hydroxytryptamine 2B (5-HT_2B) receptor represents a relatively little studied target of serotonergic drugs of abuse. However, studies suggest the involvement of 5-HT_2B receptors in the mechanism of action of...
The importance of treating concurrent Post-Traumatic Stress Disorder (PTSD) and substance use with psychedelics is a controversial topic, hampered in part by a lack of empirical evidence and rigidity of substance scheduling. Traditional treatments for concurrent PTSD and substance use concerns are compartmentalized, with clinicians focusing on one condition over the other. In addition,...
To conduct Brazil's first clinical trial employing 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for post-traumatic stress disorder (PTSD), given its high prevalence resulting from epidemic violence. Of 60 volunteers, four matched the inclusion & exclusion criteria. Three patients with PTSD secondary to sexual abuse (diagnosed by the Structured Clinical Interview for DSM-IV...
Despite advances in the field, eating disorders (EDs) remain very challenging disorders to treat, especially when comorbid with posttraumatic stress disorder (PTSD). N-methyl-3,4-methylenedioxyamphetamine (MDMA)-assisted psychotherapy for treatment refractory PTSD shows great promise, with two-thirds of participants achieving full remission at 1 year or more at follow-up. PTSD is a common...
Healing from trauma occurs in a relational context, and the impacts of traumatic experiences that result in post-traumatic stress disorder (PTSD) go beyond the diagnosis itself. To fully understand a treatment for PTSD, understanding its impact on interpersonal, relational, and growth outcomes yields a more fulsome picture of the effects of the treatment. The current paper examines these...