Neuropsychopharmacology
June 2000
W B West, A Lou, K Pechersky et al.
Drugs such as PCP and MK-801 can cause psychotic reactions in humans by antagonizing NMDA receptors. This action is ultimately toxic to certain cortical neurons and may be one mechanism underlying neurodegenerative diseases, including schizophrenia. It has been reported that hallucinogens such as LSD, DOM, and DOI can block the neurotoxic effects of NMDA antagonists, possibly by activating...
Biological Psychiatry
May 1, 2000
M Tomitaka, S Tomitaka, S Rajdev et al.
N-Methyl-D-aspartate (NMDA) receptor antagonists, including phencyclidine (PCP) and dizocilpine (MK801), cause schizophrenialike psychosis in humans, and produce vacuolated neurons in the cingulate and retrosplenial cortices of the rat brain. Since psychotically depressed patients and schizophrenic depressed patients may require treatment with selective serotonin reuptake inhibitors (SSRIs), it...
Brain research. Brain research reviews
March 2000
George K. Aghajanian, Gerard J. Marek
The serotonin (5-HT) hypothesis of schizophrenia arose from early studies on interactions between the hallucinogenic drug LSD (D-lysergic acid diethylamide) and 5-HT in peripheral systems. More recent studies have shown that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and phenethylamines (e.g. , mescaline), produce their central effects through a common...
Experimental and Clinical Psychopharmacology
2000
A. K. Goodwin, L. E. Baker
44 citations
(+/-)-3,4-Methylenedioxymethamphetamine (MDMA) produces subjective effects in humans that are similar to, but distinguishable from, those of psychostimulants. Drug discrimination studies in nonhumans have yielded inconsistent results regarding the similarities between MDMA and the psychomotor stimulant d-amphetamine. This study successfully used a 3-choice operant procedure to establish MDMA...
Journal of Psychoactive Drugs
2000
M C Mcbride
71 citations
A review of the neuropharmacology of the alleged hallucinogen bufotenine is presented, including recent experimental results showing activity similar to LSD and other known hallucinogens (psilocin and 5-MeO-DMT) at the purported hallucinogenic serotonin (5-HT) receptors, 5-HT2A and 5-HT2C. In addition, current reports of computer modeling of the receptors and ligand binding sites give evidence...
The Journal of Creative Behavior
December 1, 1999
Jos Ten Berge
51 citations
ABSTRACT Language barriers have largely prevented American scholars from learning about European studies concerning drugs and creativity. An art historian reports on several Swiss, English, French and German studies conducted from the 1940s to the 1970s, offering new data in a research area that has been banned since drugs like mescalin, psilocybin, and LSD became illegal. Different views of...
Pharmacology, Biochemistry, and Behavior
October 1999
J B Appel, W B West, W G Rolandi et al.
In an attempt to increase the selectivity of drug discrimination, rats were trained to discriminate LSD (0.08 mg/kg) from a group of "other" compounds consisting of cocaine (10 mg/kg), pentobarbital (5 mg/kg), and saline. Acquisition of this LSD-other discrimination was rapid (31 days) in chambers equipped with retractable levers and did not differ significantly from that of a group of animals...
Neuropsychopharmacology
August 1999
George K. Aghajanian, Gerard J. Marek
This brief review traces the serotonin (5-HT) hypothesis of the action of hallucinogenic drugs from the early 1950s to the present day. There is now converging evidence from biochemical, electrophysiological, and behavioral studies that the two major classes of psychedelic hallucinogens, the indoleamines (e.g., LSD) and the phenethylamines (e.g., mescaline), have a common site of action as...
Journal of Medicinal Chemistry
March 1, 1999
Joseph B. Blair, Danuta Marona‐lewicka, Arthi Kanthasamy et al.
63 citations
The synthesis and biological activity of 6-[2-(N, N-dimethylamino)ethyl]-4H-thieno[3,2-b]pyrrole (3a) and 4-[2-(N, N-dimethylamino)ethyl]-6H-thieno[2,3-b]pyrrole (3b), thienopyrroles as potential bioisosteres of N,N-dimethyltryptamine (1a), are reported. Hallucinogen-like activity was evaluated in the two-lever drug discrimination paradigm using LSD- and DOI-trained rats. Neither 3a nor 3b...
Journal of Psychoactive Drugs
December 1, 1998
Charles S. Grob, George Greer, Mariavittoria Mangini
15 citations
(1998). Editors' Introduction: Hallucinogens at the Turn of the Century. Journal of Psychoactive Drugs: Vol. 30, Therapeutic Ue of Hallucinogens, pp. 315-319.