The role of 5-HT2A-mediated stimulation of phosphoinositide hydrolysis in the discriminative effects of hallucinogens was investigated in PC12 cells stably expressing the rat 5-HT2A receptor (PC12-5-HT2A cells). The hallucinogenic compounds, D-lysergic acid diethylamide (LSD), (-)2,5-dimethoxy-4-methylamphetamine (DOM), psilocybin, N,N-dimethyltryptamine (DMT), 5-methoxy-N,N-dimethyltryptamine...
Many observers see geometric visual hallucinations after taking hallucinogens such as LSD, cannabis, mescaline or psilocybin; on viewing bright flickering lights; on waking up or falling asleep; in “near-death” experiences; and in many other syndromes. Klüver organized the images into four groups called form constants: (I) tunnels and funnels, (II) spirals, (III) lattices, including honeycombs...
This article examines drug substitution with regard to hallucinogens (ayahuasca, ibogaine, peyote and LSD) set within the concept of redemption. The model examines both religious and secular approaches to the contemporary use of hallucinogens in drug substitution, both by scientists and in religious settings worldwide. The redemptive model posits that the proper use of one psychoactive...
Der 1952 verstorbene Landarzt Eduard Renner hat in seinem Buch «Goldener Ring über Uri» das magische Denken der Urner Bergler beschrieben.Ihm war diese Welt nicht Aberglaube, sondern letzter Zeuge eines uralten, faszinierenden Weltbildes.Bergkristalle, Pflanzen, Tiere und Menschen verändern ihre Form, verschwinden und sind plötzlich wieder da, oder sind es gleichzeitig an verschiedenen...
In this occasional series we record the views and personal experience of people who have specially contributed to the evolution of ideas in the Journal's field of interest. Murray Jarvik's long and fruitful career in research and teaching spans the 50-year period beginning before the explosion of interest in psychopharmacology up to the present. His studies on LSD, among the first ever...
This essay will examine the regulation of altered states of consciousness and the criminalization of specific drags against the backdrop of Christian ideology, colonization, and capitalism. In addition, this essay reveals how the regulation of altered states of consciousness contributes both to race, class, and gender Inequality as well as to the regulation and suppression of spiritual belief,...
A series of fluorinated analogues of the hallucinogenic tryptamines N,N-diethyltryptamine (DET), 4-hydroxy-N,N-dimethyltryptamine (4-OH-DMT, psilocin), and 5-methoxy-DMT was synthesized to investigate possible explanations for the inactivity of 6-fluoro-DET as a hallucinogen and to determine the effects of fluorination on the molecular recognition and activation of these compounds at serotonin...
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") is a recreational drug of increasing use among youth because of its apparent entactogenic properties, such as euphoria, friendliness, closeness, and empathy. However, experimental studies have shown MDMA to be neurotoxic. Data on pharmacologic actions of MDMA in humans are limited. The authors conducted a randomized, double-blind, crossover,...
Under certain conditions or in an overdose setting, several classes of drugs can induce illusions, hallucinations, or delusions. However, one of the hallmark features of hallucinogens or psychedelic agents is their ability to induce states of altered or distorted perception, thought, and mood. Many hallucinogens produce classic sympathomimetic effects; that is, hyperactivity, mydriasis (dilated...