The exploration of possible therapeutic benefits of hallucinogenic substances has undergone a revitalization in the past decade. This literature review investigated the published literature regarding the psychotherapeutic uses of hallucinogens in psychiatric disorders. The results showed that a variety of substances have been evaluated in the treatment of psychiatric disorders, including...
Microdosing classic psychedelics (e.g., LSD [lysergic acid diethylamide] and psilocybin) is the practice of taking small amounts of these substances to bring about various positive life changes. Little is known about the subjective experiences and perceptions of those who engage in the practice. Accordingly, we use the sociology of accounts as a theoretical framework to explore the ways that...
August 12, 2019Beatriz Martins, Afonso Homem de Matos, Manuel Sardinha
Background and aimsPhysical suffering of a person under palliative care is frequently associated to psychological (or existential) suffering. In fact, people with potentially untreatable diseases present a higher prevalence of depressive symptoms and anxiety than general population. Nevertheless, conventional therapeutic options seem to be insufficient.Inspired by 1950-1960u2019s studies, some...
The thesis results from ethnographic work and reports two practices that occurred in Portugal: a) compulsive gambling as a disease and its continued definition through participation in a self-help group called Anonymous Families and b) the trance party, a place where electronic music dance is considered as the apex of participation. In spite of the contrast between these two practices, in both...
Background: In the past few years, the issue of ‘microdosing’ psychedelics has been openly discussed in the public arena where claims have been made about their positive effect on mood state and cognitive processes such as concentration. However, there are very few scientific studies that have specifically addressed this issue, and there is no agreed scientific consensus on what microdosing is....
This article covers the renaissance of classical psychedelic drugs such as psilocybin and LSD plus 3,4-methylene dioxymethamphetamine (MDMA-ecstasy) in psychiatric research. These drugs were used quite extensively before they became prohibited. This ban had little impact on recreational use, but effectively stopped research and clinical treatments, which up to that point had looked very...
Classic serotonergic psychedelics are remarkable for their capacity to induce reversible alterations in consciousness of the self and the surroundings, mediated by agonism at serotonin 5-HT2A receptors. The subjective effects elicited by dissociative drugs acting as N-methyl-D-aspartate (NMDA) antagonists (e.g. ketamine and phencyclidine) overlap in certain domains with those of serotonergic...
The subjective effects of drugs are related to the kinds of feelings they produce, such as euphoria or dysphoria. One of the methods that can be used to study these effects is the drug discrimination procedure. Many researchers are trying to elucidate the mechanisms that underlie the discriminative stimulus effects of abused drugs (e.g., alcohol, psychostimulants, and opioids). Over the past...
Abstract Background Microdosing with psychedelics has gained considerable media attention where it is portrayed as a performance enhancer, especially popular on the work floor. While reports are in general positive, scientific evidence about potential negative effects is lacking aside from the prevalence and motives for use. The present study addressed this gap by surveying psychedelic users...
Delving into the unfolding correspondence that fills these lovingly crafted pages affords pleasure and no small dollop of prophecy as they chronicle the great friendship that manifested during the last decade of Aldous Huxley’s life and Humphrey Osmond’s most fertile period of research. Topics run from both men’s fascination with opening the doors of the mind to explore the biochemistry of...