Psychiatry Research
October 1, 2026
Jaime Rojas-Hernández, Lucas F Borkel, Ángelo Santana Del Pino et al.
This study examines acute and delayed adverse reactions reported in naturalistic psychedelic use, focusing on their associations with substance-use patterns, contextual variables, and user motivations. Using an online survey incorporating the Psychedelic Use Scale, data were collected from a large naturalistic sample (N=1022) to analyze patterns of self-reported adverse reactions. Acute adverse...
Aracê.
September 29, 2026
Renato Lemes Peixoto, Lígia Freitas
A Ayahuasca é uma preparação de origem amazônica tradicionalmente produzida a partir da combinação de Banisteriopsis caapi e Psychotria viridis, contendo compostos biologicamente ativos como N,N-dimetiltriptamina (DMT), harmina, harmalina e tetrahidroharmina. Nas últimas décadas, sua utilização ultrapassou os contextos tradicionais e religiosos amazônicos, alcançando centros urbanos e...
Scientific Reports
September 24, 2026
Giammarco di Gregorio, Basset Sophia, Harjot Manmohan et al.
Abstract Depression and anxiety affect one in five adults and vary across the lifespan; while prevalence generally declines with age until midlife, later life is marked by a re-emergence of symptoms. Although clinical trials suggest classic psychedelics (e.g., psilocybin, LSD) and non-classic psychedelics (e.g., MDMA, ketamine) may alleviate these symptoms, it remains unclear how these...
Zenodo (CERN European Organization for Nuclear Research)
September 24, 2026
George Wanjau
preprint
This essay argues that the stable entities of experience and cosmology are held forms: patterns of relation that have stabilized enough to persist, hold a boundary, and be located. It begins with cases where those anchors loosen: sensory deprivation, long contemplative retreats, near-death experiences, and the involuntary LSD dosing of James "Whitey" Bulger under MK-Ultra. In each, the...
European Neuropsychopharmacology
September 19, 2026
Maia Mallevays, Lucie Berkovitch
Classic psychedelics, including lysergic acid diethylamide (LSD), psilocybin, and dimethyltryptamine (DMT), have re-emerged as promising treatments for psychiatric conditions linked to suicidality. However, rare reports of increased suicidality potentially associated with psychedelic use have raised safety concerns. This article examines the complex relationship between psychedelics and...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
September 18, 2026
Ewelina Cyrano, Joanna Gołębiowska, Piotr Popik et al.
Psychedelics and psychostimulants produce subjective and often positive affective effects in humans. In rats, positive affective states are often associated with frequency-modulated ultrasonic vocalizations (USVs). We examined whether the hallucinogenic 2,5-dimethoxy-4-iodoamphetamine (DOI; 1.25-2.5 mg/kg) and LSD (0.04-0.08 mg/kg), the non-hallucinogenic lisuride (0.03 or 0.3 mg/kg) and the...
September 17, 2026
Casey Rae
Abstract Chapter Five charts how psychedelic culture and the early Grateful Dead catalyzed a new American vocabulary for transformation—spiritual, aesthetic, and political—while revealing the tensions embedded in that promise. It opens with Richard Alpert’s 1966 encounter with the Dead at the Fillmore, where Primal Dead’s volatile improvisation, light shows, and collective ecstasy suggested a...
September 17, 2026
Casey Rae
Abstract Chapter Four follows the “turning wheel” of psychedelic awakening as it moved from private epiphany to collective ritual, tracing the converging paths of Ken Kesey’s Pranksters, Timothy Leary’s Millbrook circle, and the embryonic Grateful Dead. It begins with Furthur, the Day-Glo-painted Prankster bus that carried a crew of LSD-fueled experimenters across America in 1964—part road...
npj Mental Health Research
September 17, 2026
U. Lueken, Isabel Dziobek, Martha N. Havenith et al.
High ventilation breathwork (HVB) can induce altered states of consciousness with phenomenological similarities to those reported following administration of serotonergic psychedelics such as lysergic acid diethylamide (LSD), psilocybin or ayahuasca. Non-pharmacological methods capable of reliably eliciting such states may provide scalable models for investigating therapeutic mechanisms...
Psychedelic Medicine
September 14, 2026
Vasileios Chytas, Georgios Tsimploulis, Dimitrios Chytas
Purpose: Ketamine and classic psychedelics have recently gained increased scientific interest regarding their role in pain management, while there is evidence that pain induces neural connectivity changes. We performed a scoping review to investigate the correlation of ketamine and classic psychedelics with pain-related neural connectivity, aiming to find potential therapeutic targets for these...