Addiction
July 1, 2001
Sarah Riley, Charlotte James, Danielle Gregory et al.
172 citations
Aims . To describe the patterns of drug use at dance (rave) events in terms of prevalence, frequency, type of drugs used, patterns of use, access and risk‐associated behaviours. Design . Self‐selecting participant‐completed survey. Setting . Three dance events in Edinburgh, Scotland, UK. Participants . One hundred and twenty‐two drug users (57% males, 43% females), 90% of whom were in...
Psychopharmacology
February 22, 2001
Jordi Riba, Antoni Rodrı́guez-fornells, Gloria Urbano et al.
302 citations
RationaleAyahuasca is a South American psychoactive beverage that contains the naturally occurring psychedelic agent N,N-dimethyltryptamine (DMT). This "tea" has been used for centuries in religious and medicinal contexts in the rain forest areas of South America and is presently gaining the attention of psychedelic users in North America and Europe.ObjectivesIn the present study, the...
March 9, 2000
John C.m. Brust
Abstract Psilocybin and psilocin are indolealkylamines present in Central American Psilocybe species of mushrooms and in Panaeolus mushroom species of the United States (3,4). For thousands of years, Mexican Native Americans have eaten Psilocybe mushrooms ritualistically for their hallucinatory and psychedelic (“mind-revealing”) properties. In the United States during the 1980s, recreational...
Human Psychopharmacology: Clinical and Experimental
2000
Sean P. Barrett, Jennifer Archambault, Marla Engelberg et al.
11 citations
This study investigated possible interactions between alcohol and hallucinogens in 22 lysergic acid diethylamide (LSD) and/or psilocybin users through retrospective structured interviews. Of those who had used LSD with alcohol, 86;7 per cent reported a complete blockade of subjective alcohol effects, while the remaining cases reported a diminished response. In addition, 60 per cent of...
Pharmacology, Biochemistry, and Behavior
July 1, 1999
Jerrold C Winter, Scott Helsley, David Fiorella et al.
14 citations
In a previous study it was observed that fluoxetine potentiates the stimulus effects of lysergic acid diethylamide (LSD). In the present investigation, stimulus control was established in groups of rats using as training drugs the hallucinogens lysergic acid diethylamide (LSD); 0.1 mg/kg), (-)-2,5-dimethoxy-4-methylamphetamine [(-)-DOM; 0.56 mg/kg], ibogaine (10 mg/kg), and...
Pharmacopsychiatry
July 1, 1998
Franz X. Vollenweider
131 citations
Recent research into the pharmacological mechanism of hallucinogens (LSD, psilocybin) and dissociative anesthetics (PCP, ketamine) suggest that multiple neurotransmitter systems are involved in drug-induced and possibly also in naturally occurring psychoses. Specifically, animal models suggest that a dysbalance between serotonin, glutamate, and dopamine in the limbic cortico-striato-thalamic...
Phytomedicine
April 1, 1998
Neville S. Arachchige Don, Bruce E. Mcdonough, Gabriel Acácio de Moura et al.
33 citations
EEG data were recorded under field conditions from 11 members of the Santo Daime Doctrine, a Brazilian shamanistic religion, before and after ingesting the psychoactive alkaloid preparation, ayahuasca, or daime, as they term it. Post-ingestion, we observed increases in power in the 36-44 Hz frequency band ("40 Hz") from the left occipital-temporal-parietal scalp electrodes in the eyes-closed...
Journal of Medicinal Chemistry
September 1, 1997
Aaron Monte, Steve R. Waldman, Danuta Marona‐lewicka et al.
89 citations
Dihydrobenzofuran and tetrahydrobenzodifuran functionalities were employed as conformationally restricted bioisosteres of the aromatic methoxy groups in the prototypical hallucinogen, mescaline (1). Thus, 4-(2-aminoethyl)-6,7-dimethoxy-2,3-dihydrobenzofuran hydrochloride (8) and 1-(8-methoxy-2,3,5,6-tetrahydrobenzo[1,2-b:5,4-b']difuran-4-yl)-2- aminoethane hydrochloride (9) were prepared and...
Molecular Pharmacology
July 1, 1996
N Almaula, Barbara J. Ebersole, J A Ballesteros et al.
An important determinant of the neurobehavioral responses induced by a drug is its relative receptor selectivity. The molecular basis of ligand selectivity of hallucinogenic and nonhallucinogenic compounds of varying structural classes for the human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors was investigated with the use of reciprocal site-directed mutagenesis. Because these two closely...
Behavioural Pharmacology
April 1, 1995
Lisa E Baker, Jonathan M. Broadbent, E. K. Michael et al.
52 citations
The discriminative stimulus effects of the stereoisomers of 3,4-methylenedioxymethamphetamine (MDMA) were studied in rats trained to discriminate 1.25mg/kg of (+)-MDMA or 3.5mg/kg of (-)-MDMA from saline, in a two lever, water-reinforced, drug discrimination situation. The isomers of MDMA and 3,4-methylenedioxyamphetamine (MDA) substituted completely for both training drugs. The stimulants...