Risperidone, a novel antipsychotic agent, is an antagonist of postsynaptic serotonin-2 and dopamine D2 receptors. In certain individuals, the hallucinogenic drug lysergic acid diethylamide (LSD) is associated with apparently lifelong continuous visual disturbances, characterized in DSM-IV as hallucinogen-persisting perception disorder (HPPD). Because the hallucinogenic mechanism of LSD is known...
We have described three patients in whom persistent palinopsia developed following ingestion of LSD. Clinicians should inquire about past LSD use in all patients who initially have seemingly spontaneous, isolated palinopsia. Recognition of this distinctive clinical syndrome associated with LSD use might avoid unnecessary anxiety and excessive diagnostic tests for patients with this disorder.
Systematic desensitization in conjunction with other behavior techniques was utilized to treat a client who for 5 months was experiencing spontaneous recurrences of LSD effects. Besides the elimination of the target symptoms (flashback effects), additional desired changes occurred on both cognitive-affective and behavioral levels. A theoretical explanation of LSD flashback effects based on the...
This study describes the short-term effects of administering LSD to normals as measured by pre and one-week-post-LSD tests of anxiety, attitudes, and performance. The hypothesis tested was that LSD would produce a rapid lowering of defenses resulting in (1) lower anxiety, (2) attitudinal changes, particularly in the form of decreased dogmatism and projection of aggression, and (3) increases in...
The striking mental changes induced by the diethylamide of lysergic acid (hereafter referred to as LSD) have been studied extensively in Europe,* Great Britain,† and the United States.‡ In minute doses (20γ to 120γ) LSD induces a peculiar mental state characterized by anxiety, signs of autonomic dysfunction, perceptual distortion (chiefly visual), alterations in mood and affect, synesthesias,...
Lysergic acid diethylamide (LSD-25 Sandoz) given orally in single doses as low as 20 micrograms produces depersonalization, derealization, and increased imagery in "normal" individuals. Larger doses are required to produce the same effect in psychotic patients. Of 15 patients with depressive reactions, 3 recovered and 4 improved after one month's treatment with daily oral doses of 20-100...