Page 424 of 449: studies 4,231 to 4,240 of 4,486, newest first. Back to the ketamine overview
The Journal of Clinical Psychiatry December 27, 2017 Chittaranjan Andrade
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.To the Editor: Dr Bartoli and colleagues suggest that the dissociative and antidepressant effects of ketamine are two sides of the same coin or, to use a different metaphor, that they go hand in hand. This is hardly surprising. The efficacy and adverse effects...
Journal of Pharmacology and Experimental Therapeutics December 2017 Linda J Bristow, Jyoti Gulia, Michael R Weed et al.
(R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169) and the phosphate prodrug 4-((3S,4S)-3-fluoro-1-((R)-1-(4-methylbenzyl)-2-oxopyrrolidin-3-yl)piperidin-4-yl)phenyl dihydrogen phosphate (BMS-986163) were identified from a drug discovery effort focused on the development of novel, intravenous glutamate N-methyl-d-aspartate 2B receptor...
Neuronal signaling December 2017 Alexandra M. Thomas, Ronald S. Duman
Depression is a chronic, debilitating, and common illness. Currently available pharmacotherapies can be helpful but have several major drawbacks, including substantial rates of low or no response and a long therapeutic time lag. In pursuit of better treatment options, recent research has focussed on rapid-acting antidepressants, including the N-methyl-D-aspartate (NMDA) receptor (NMDAR)...
Neuropharmacology November 20, 2017 Christopher Timmermann, Meg J. Spriggs, Mendel Kaelen et al. 83 citations
Under the predictive coding framework, perceptual learning and inference are dependent on the interaction between top-down predictions and bottom-up sensory signals both between and within regions in a network. However, how such feedback and feedforward connections are modulated in the state induced by lysergic acid diethylamide (LSD) is poorly understood. In this study, an auditory oddball...
Neuropharmacology November 1, 2017 Chrislean Jun Botanas, June Bryan De la Peña, Raly James Perez Custodio et al.
Depression afflicts around 16% of the world's population, making it one of the leading causes of disease burden worldwide. Despite a number of antidepressants available today, the delayed onset time and low remission rate of these treatments are still a major challenge. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown to produce rapid and sustained antidepressant effects...
bioRxiv (Cold Spring Harbor Laboratory) October 16, 2017 Suresh Muthukumaraswamy, David T. J. Liley 1 citation preprint
Abstract Neurophysiological recordings are dominated by arhythmical activity whose spectra can be characterised by power-law functions, and on this basis are often referred to as reflecting scale-free brain dynamics (1/ f β ). Relatively little is known regarding the neural generators and temporal dynamics of this arhythmical behaviour compared to rhythmical behaviour. Here we used Irregularly...
British Journal of Pharmacology October 1, 2017 Mary T. Zanda, Paola Fadda, S Antinori et al.
Methoxetamine (MXE) is a novel psychoactive substance that is emerging on the Internet and induces dissociative effects and acute toxicity. Its pharmacological effects have not yet been adequately investigated. We examined a range of behavioural effects induced by acute administration of MXE (0.5-5 mg·kg-1 ; i.p.) in rats and whether it causes rapid neuroadaptive molecular changes. MXE (0.5-5...
European Neuropsychopharmacology October 1, 2017 Michael D. Wunderli, Matthias Vonmoos, Marina Fürst et al. 37 citations
Chronic use of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") has repeatedly been associated with deficits in working memory, declarative memory, and executive functions. However, previous findings regarding working memory and executive function are inconclusive yet, as in most studies concomitant stimulant use, which is known to affect these functions, was not adequately controlled for....
Journal of Psychoactive Drugs September 22, 2017 Joseph J Palamar
Ecstasy (MDMA) has regained popularity in powder and crystalline form, known as Molly. However, it is unknown whether all Molly users are aware that Molly is ecstasy. A total of 1045 nightclub/festival-attending adults in New York City were surveyed about ecstasy/MDMA/Molly use in 2016. Users were asked if they agreed that "Molly is (or is supposed to be) ecstasy/MDMA." Of the 43.5% reporting...
Global Journal of Health Science September 18, 2017 Ahmed Al-Imam 6 citations
BACKGROUND: Novel psychoactive substances (NPS) can be classified based on their safety for use into low-risk and high-risk. High-risk NPS can be either lethal or poisonous. Fatalities can be either pharmacological or behavioural-induced, including suicide and homicide.MATERIALS & METHODS: Observational analysis, including retrospective, were implemented across; Google Trends, PubMed/MedLine...