Journal of Pharmacology and Experimental Therapeutics
February 1, 2008
Jun-Xu Li, Kenner C Rice, Charles P France
51 citations
Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and related drugs have been studied extensively in rodents, although the generality of those findings across species is not known. The goals of this study were to see whether monkeys could discriminate DOM and to characterize the DOM discriminative stimulus by studying a variety of drugs, including those...
Journal of ethnicity in substance abuse
2008
Kit Sang Leung, Jih-Heng Li, Wen-Ing Tsay et al.
Research among Asian users of methylenedioxy methamphetamine (MDMA), also known as Ecstasy, is rare. To evaluate the feasibility of a study on the abuse of and dependence on Ecstasy, two focus groups of users (n= 12) and health professionals (n=7) were conducted in Taiwan. Major results included blatant human testing with "candy and dinosaur girls" and a specific sequence of drugs called a...
Novartis Foundation symposium
2008
Daniel C Javitt
Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide. Traditional models of schizophrenia have emphasized dopaminergic dysfunction. Over the last 15 years, however, glutamatergic models have become increasingly mainstream, and account for features of the disorder that are poorly explained by dopaminergic dysfunction alone. Glutamatergic models, such as...
Journal of Psychopharmacology
May 1, 2007
Charles H Large
N-methyl-D-aspartate (NMDA) receptor antagonists, such as ketamine and phencyclidine, induce perceptual abnormalities, psychosis-like symptoms, and mood changes in healthy humans and patients with schizophrenia. The similarity between NMDA receptor antagonist-induced psychosis and schizophrenia has led to the widespread use of the drugs to provide models to aid the development of novel...
Handbook of Contemporary Neuropharmacology
March 2, 2007
María Isabel Colado, Esther O'Shea, Alfred Richard Green
AbstractThe use of the club drugs 3, 4‐methylenedioxymethamphetamine (MDMA, “ecstasy”), gamma‐hydroxybutyrate (GHB), flunitrazepam (Rohypnol), ketamine and LSD is a popular practice among young people especially during all‐night dance parties or “raves“ due to their ability to enhance social experiences and/or alter perception. These substances belong to different classes of drugs: MDMA is an...
European Psychiatry
February 17, 2007
Gordana Dedić, Slaviša Djurdjevic
Abstract Ketamine is an N-methyl-D-aspartate (NMDA) antagonist that has become increasingly recognized and utilized in the treatment of post-operative pain as a way to reduce opioid use. Overall ketamine is generally well tolerated, however it is associated with transient hypertension and neurologic "emergence phenomena" manifesting as dream-like states, irrational behavior, and delirium. From...
The California journal of emergency medicine
February 1, 2007
T. Bey, Anar J. Patel
The California Journal of Emergency Medicine VIII:1 February 2007 Page Clinical Review Phencyclidine Intoxication and Adverse Effects: A Clinical and Pharmacological Review of an Illicit Drug Tareg Bey, MD and Anar Patel, MD Department of Emergency Medicine, University of California, Irvine, Medical Center Orange, California. Correspondence: Tareg Bey, MD, FACEP, FAAEM Department of Emergency...
International review of neurobiology
2007
Daniel C Javitt
Schizophrenia is a serious mental disorder that affects up to 1% of the population worldwide. As of yet, neurochemical mechanisms underlying schizophrenia remain unknown. To date, the most widely considered neurochemical hypothesis of schizophrenia is the dopamine hypothesis, which postulates that symptoms of schizophrenia may result from excess dopaminergic neurotransmission particularly in...
Archives of General Psychiatry
August 1, 2006
Carlos A. Zarate, Jaskaran Singh, Paul J. Carlson et al.
3,762 citations
CONTEXT: Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are sustained would have an enormous impact on patient care. Converging lines of evidence suggest the role of the glutamatergic system in the...
Brazilian Journal of Medical and Biological Research
April 1, 2006
Antônio Waldo Zuardi, José A. Crippa, Jaime E. C. Hallak et al.
411 citations
A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of delta9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent which is devoid of the typical effects of the plant. This observation led us to suspect that CBD could have anxiolytic...