Page 38 of 448: studies 371 to 380 of 4,475, newest first. Back to the ketamine overview
Mediterranean Journal of Emergency Medicine & Acute Care April 8, 2026 Curtis Marino
Acute suicidal ideation (SI) represents about 1% of all adult emergency department (ED) visits in the U.S. and has increased over the past few decades, especially in the wake of the COVID-19 pandemic.
Molecular Psychiatry April 8, 2026 Daniel Dautan, Anderson Camargo, Per Svenningsson
The discovery that a single subanesthetic dose of (R,S)-ketamine induces rapid and long-lasting antidepressant effects by a completely different mechanism represents one of the most substantial break-throughs in depression pharmacotherapy. The recent study in Nature by Yue and colleagues represents a signi fi cant conceptual and technical advance by identifying NMDA-independent transient...
Frontiers in Microbiology April 7, 2026 Zhilong Xu, Jie Zhang, Canrun Hu et al.
Chronic ketamine exposure results in psychotic and cognitive symptoms that resemble those found in patients with schizophrenia. Emerging evidence suggests that patients with schizophrenia exhibit gut microbiota dysbiosis and decreased levels of short-chain fatty acids (SCFAs) and BDNF, which are related to the severity of psychotic and cognitive symptoms. Dietary inulin can regulate gut...
BMC Psychiatry April 6, 2026 Michael Schlegelmilch, Amy C. Plint, Nicholas Barrowman et al.
BACKGROUND: Suicidal ideation (SI) is a common reason for emergency department (ED) visits by adolescents. While intravenous (IV) ketamine rapidly reduces SI in adults, its efficacy in adolescents remains unstudied. We assessed the feasibility of a trial of a single dose IV ketamine to reduce adolescent SI in the ED. METHODS: This double-blind, randomized, placebo-controlled pilot trial was...
Research Journal of Pharmacy and Technology April 3, 2026 Rafiya Ahmadi, Pinki Verma
Aim: The present research is to evaluate the antioxidant and antipsychotic potential of Desmodium gangeticum on the ketamine-induced experimental psychosis model in rats with a focus on TNF-α Regulation. Materials and Methods: The root was collected, desiccated, and finely ground. Extraction was conducted using 98% ethanol in a Soxhlet apparatus. This study included a preliminary phytochemical...
Journal of Paramedic Practice April 2, 2026 Joshua Barker
Aim: This study explored the experiences of patients who received an analgesic or sedative (sub-anaesthetic) dose of prehospital ketamine and examined common themes. Background: Ketamine is a powerful dissociative anaesthetic used by prehospital critical care teams. Among its many effects are dissociative episodes, hallucinations and periods of amnesia. It is unclear how these affect patients'...
FOCUS: The Journal of Lifelong Learning in Psychiatry April 1, 2026 Thomas Kun Pak, Stephen Kimatian, Graham J Emslie et al.
Ketamine is a well-established anesthetic agent that is gaining increasing recognition for its diverse therapeutic applications, including the management of chronic pain, refractory status epilepticus, major depressive disorder, and suicidality. Although it has been used clinically since the 1960s, multiple clinical trials with ketamine and esketamine in adults and pediatric populations are...
FOCUS: The Journal of Lifelong Learning in Psychiatry April 1, 2026 Rachel Fremont, Marcella Corwin, Greta Kandel et al.
Over the past 25 years, the field of psychiatry has seen a rapid expansion of ketamine treatment services offered for the off-label management of depression, anxiety, and other psychiatric disorders as well as the U.S. Food and Drug Administration's approval of intranasal esketamine, the S-enantiomer of ketamine, for treatment-resistant depression and suicidal depression. In this review, the...
Journal of Experimental Pharmacology April 1, 2026 V. A. Chukwu, G. Anyanwu, N. Nto et al.
Introduction Schizophrenia involves dopaminergic dysregulation, oxidative stress, and glial activation within motor–cognitive circuits. Mangiferin, a polyphenolic C-glucoside from Mangifera indica, exerts antioxidant and anti-inflammatory effects partly via modulation of nuclear factor erythroid 2–related factor 2 (Nrf2) signaling. This study evaluated whether mangiferin attenuates...
Saudi Pharmaceutical Journal April 1, 2026 Mohammed M. Heikal, Ahmed F. Mohamed, Nora O. Abdel Rasheed et al.
The interplay between cAMP/PKA and neuroplasticity involves intricate signaling pathways that are crucial for brain function and are frequently disrupted in schizophrenia. This study sought to examine the potential neuroprotective effects of formoterol on ketamine-induced schizophrenia-like behaviors with emphasis on several PKA downstream crucial targets for schizophrenia management. Male mice...