Introduction Schizophrenia involves dopaminergic dysregulation, oxidative stress, and glial activation within motor–cognitive circuits. Mangiferin, a polyphenolic C-glucoside from Mangifera indica, exerts antioxidant and anti-inflammatory effects partly via modulation of nuclear factor erythroid 2–related factor 2 (Nrf2) signaling. This study evaluated whether mangiferin attenuates...
Treatment-resistance is a frequent condition for obsessive-compulsive disorder (OCD). Over the past decades, a lot of effort has been made to address this issue, and several augmentation strategies of serotonergic drugs have been investigated. Antidopaminergic drugs are considered the first choice as augmentation strategy for treatment-resistant OCD patients, but they seem to work only for a...