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Experiences of trauma patients given subanaesthetic doses of ketamine

Joshua Barker

Journal of Paramedic Practice April 2, 2026 DOI: 10.12968/jpar.2025.0021 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Qualitative phenomenological study Peer reviewed
Sample size 8
Population Patients who received a sub-anaesthetic dose of prehospital ketamine
Intervention Ketamine
Dose sub-anaesthetic dose
Topics Esketamine Ketamine
Key findings Patients viewed ketamine as beneficial, citing amnesia as useful for mental recovery. Altered reality was mostly pleasant, though two participants reported dysphoria during transitions. Clinicians' communication influenced experiences, and patients perceived motion as it happened.

Abstract

Aim: This study explored the experiences of patients who received an analgesic or sedative (sub-anaesthetic) dose of prehospital ketamine and examined common themes.

Background: Ketamine is a powerful dissociative anaesthetic used by prehospital critical care teams. Among its many effects are dissociative episodes, hallucinations and periods of amnesia. It is unclear how these affect patients' processing of trauma.

Method: A qualitative phenomenological approach was used, with eight patients interviewed and thematic analysis carried out.

Findings: Four major themes arose: amnesia caused by ketamine was beneficial, with patients saying it was useful for mental recovery not to remember unpleasant memories; participants experienced varying degrees of altered reality, which was mainly pleasant although two reported dysphoria related to transition into and out of ketamine's effects; clinicians affected patients' experiences, especially around telling them about ketamine's effects; and patients seemed to perceive motion as it happened.

Conclusions: Patients saw ketamine as beneficial. Clinicians should consider their communication, including around preparing patients for receiving this drug. Further research into patients' experience of ketamine should be undertaken as no markedly dysphoric experiences were captured within this study.

Comparable studies

Other qualitative studies on ketamine, most cited first.

Study Year Design Participants
Ketamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency? 2017 Qualitative review
Holding on or letting go? Patient experiences of control, context, and care in oral esketamine treatment for treatment-resistant depression: A qualitative study. Patients with treatment-resistant depression participating in off-label oral esketamine... 2022 Qualitative study n = 17
A Cohort-Based Case Report: The Impact of Ketamine-Assisted Therapy Embedded in a Community of Practice Framework for Healthcare Providers With PTSD and Depression Healthcare providers 2022 Quality improvement evaluation with mixed methods n = 94
Predictors of Psychedelic Experience: A Thematic Analysis First-person reports of psychedelic use from the Erowid database (six reports each for... 2022 Thematic analysis n = 22
Expert Opinion on Psychedelic-Assisted Psychotherapy for People with Psychopathological Psychotic Experiences and Psychotic Disorders Experts in psychiatry, clinical psychology, medicine, and psychedelic effects 2024 Qualitative study n = 12

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