Journal of anaesthesiology, clinical pharmacology
2025
Surabhi, Poonam Kumari, Amarjeet Kumar et al.
1 citation
Emergence delirium (ED) is a common postoperative complication in pediatric patients. To avoid postoperative ED, sedative medications have been utilized in addition to general anesthesia. In this study, the primary objective was to assess the incidence of postoperative emergence of delirium at 0-, 10-, 20-, 30-, and 60-min intervals. Secondary objective was to assess postoperative analgesia (0,...
Frontiers in Pharmacology
2025
Jing Wang, Yulei Hao, Di Ma et al.
14 citations
The recreational abuse of addictive drugs poses considerable challenges to public health, leading to widespread neurotoxicity and neurological dysfunction. This review comprehensively examines the neurotoxic mechanisms, clinical manifestations, and treatment strategies associated with six commonly abused substances: methamphetamine, cocaine, synthetic cathinones, ketamine, nitrous oxide and...
Frontiers in Psychiatry
2025
Ella van Beers, Irene de Vries, Caroline Planting et al.
2 citations
Many people with eating disorders report having experienced childhood maltreatment or a traumatic event prior to developing an eating disorder. Although many people with eating disorders have significant traumatic exposure or symptoms of post-traumatic stress disorder, very little research has examined the effects of combined treatments for this group. The purpose of this systematic review was...
Frontiers in Pharmacology
2025
Sarah Delcourte, Amel Bouloufa, Renaud Rovera et al.
3 citations
Beside image vision, light plays a pivotal role in regulating diverse non-visual functions, including affective behaviors. Recently, bright light stimulation (BLS) was revealed to be beneficial for treating non-seasonal depression, although its mechanism of action is not fully understood. We developed a novel mouse model of refractory depression, induced through social isolation and chronic...
Frontiers in Pharmacology
2025
Elizabeth G. Neureiter, M Quincy Erickson-Oberg, Aparna Nigam et al.
4 citations
N-methyl-D-aspartate receptors (NMDARs) are ligand-gated ion channels present at most excitatory synapses in the brain that play essential roles in cognitive functions including learning and memory consolidation. However, NMDAR dysregulation is implicated in many nervous system disorders. Diseases that involve pathological hyperactivity of NMDARs can be treated clinically through inhibition by...
Drug and Alcohol Dependence
2025
James M Zech, David B. Yaden, Grant Jones
9 citations
Cannabis Use Disorder (CUD) is an increasingly prevalent disorder affecting millions of Americans each year. Psychedelic compounds have recently been investigated for their therapeutic potential in treating substance use disorders, yet no prior work has examined the relationship between naturalistic use of specific psychedelic compounds and rates of disordered cannabis use. Using a nationally...
Journal of Affective Disorders
December 15, 2024
Ethan Faries, Landon A Mabe, Ronald L Franzen et al.
13 citations
Major depressive disorder (MDD) is highly prevalent in youth. Conventional treatment paradigms primarily involve selective serotonin reuptake inhibitors (SSRIs) and psychotherapy, yet a significant proportion of this population exhibits treatment-resistant depression (TRD). In adults, interventional therapies like Electroconvulsive Therapy (ECT), repetitive Transcranial Magnetic Stimulation...
European Eating Disorders Review
December 15, 2024
Hubertus Himmerich, Beate Herpertz-Dahlmann, Sabrina Mörkl
4 citations
Blood-based biomarkers and neuroimaging techniques have improved our understanding of the underlying biology of eating disorders (EDs) and have increased our diagnostic portfolio. This editorial accompanies an article collection on novel biological approaches to treat EDs. The collection covers intermittent theta burst stimulation, therapeutic drug monitoring, pharmacological treatments...
Annals of medicine
December 1, 2024
Alaa Abd-Elsayed, Cain W Stark, Natasha Topoluk et al.
41 citations
Complex regional pain syndrome (CRPS) is a debilitating chronic pain condition that, although exceedingly rare, carries a significant burden for the affected patient population. The complex and ambiguous pathophysiology of this condition further complicates clinical management and therapeutic interventions. Furthermore, being a diagnosis of exclusion requires a diligent workup to ensure an...
Expert Opinion on Pharmacotherapy
December 1, 2024
Millie C Kirchberg, Claire Pinson, Guido K W Frank
9 citations
Anorexia nervosa (AN) has one of the highest mortality rates of all mental illnesses. No approved pharmacological treatments exist for AN, but novel neurobiological targets show promise. Studies show that in individuals with AN, there are alterations in brain neurotransmitter signaling, alongside associated mental rigidity and comorbid anxiety and depression. Available and new therapies could...