Sleep remains a complex and only partially understood neurophysiological process, with current theories often fragmented across electrophysiological, metabolic, and phenomenological domains. In this paper, we propose an advanced and integrative framework that conceptualizes rapid eye movement (REM) sleep as a state in which the brain constructs a provisional dummy model of the external world....
Abstract Xylazine, traditionally used as a veterinary sedative, has recently emerged as a new psychoactive substance, being typically ingested in combination with fentanyl derivatives and hence raising significant public health concerns. Despite its increasing prevalence, little is known about its molecular interactions with human neuroreceptors, specifically the serotonin 7 (5‐HT 7 R) and...