Australian and New Zealand Continence Journal
August 11, 2026
Janine Stirling, M. Doane, M. Simon et al.
Post-traumatic stress disorder places patients at risk for emergence agitation following surgical procedures under general anaesthesia. Gynaecological procedures, sphincteroplasty, and surgical interventions involving the pelvic floor can involve vulnerable patient positioning in theatre, with inserted catheters and sensory stimulation. Such interventions could contribute to postoperative...
European Journal of Endocrinology
August 10, 2026
Huma Humayun Khan, Jeremy Tomlinson
Abstract Ketamine is a dissociative anaesthesia which also has analgesic properties and is also used in pain management and depression1. As it produces an out-of-body and rewarding experience, there is a potential danger for abuse of this medication2.Cystitis and cholangiopathy are recognized side effects of ketamine use3,however, published data on ketamine-induced hyponatremia is scarce.The...
Journal of Affective Disorders
August 10, 2026
Discordant signals: How outcome measurement shapes interpretation of ketamine response in treatment-resistant depression.
Journal of Affective Disorders
August 10, 2026
Intravenous Ketamine reduces psychological pain in suicidal inpatients: A secondary analysis of a six-week randomized placebo-controlled trial.
Journal of Affective Disorders
August 10, 2026
Yves Martins Varela, Patrícia Cavalcanti-Ribeiro, Geovan Menezes de Sousa et al.
BACKGROUND: Ketamine is an effective rapid-acting treatment for treatment-resistant depression (TRD), producing antidepressant effects within hours of administration. Because it induces states of heightened neuroplasticity and psychological openness, psychotherapy may enhance its therapeutic effects. METHODS: This exploratory, nonrandomized, open-label clinical trial evaluated the adjunctive...
Brain Sciences
August 9, 2026
Vikas Chauhan, Fareena Khan
Ketamine produces clinical states ranging from subanesthetic analgesia and dissociation to anesthetic-dose behavioral unresponsiveness. Its electroencephalographic (EEG) effects differ from the slow-delta and frontal-alpha patterns commonly observed with GABAergic-dominant anesthetics and vary with exposure, administration kinetics, and co-administered agents. After anesthetic bolus dosing,...
Cell Death Discovery
August 8, 2026
Yuqing Liu, Jiang Jiang, Yalong Wang et al.
Depression is a common psychiatric disorder, with a higher prevalence in women than in men, and has been increasingly associated with disturbances in female reproductive health. In particular, depressive conditions may impair ovarian function and compromise oocyte quality, thereby contributing to reproductive disorders. Ketamine is a clinically effective antidepressant. However, its potential...
Artefactum
August 6, 2026
Laura Alves Dutra, Anne Karolyne Alves Martins, Marina Camarão Oliveira et al.
Introduction:Treatment-resistant depression (TRD) is defined by the persistence of depressive symptoms despite at least two adequate trials with different classes of antidepressants. Limitations of traditional monoaminergic drugs have driven the search for rapid-acting, innovative interventions such as ketamine and electroconvulsive therapy (ECT), which target neuroplasticity and the...
Journal of Medical Ethics
August 5, 2026
JingYi Zhang, Dominic Sisti
Intravenous ketamine and intranasal esketamine have shown rapid effects in reversing suicidality and improving depressive symptoms. In countries that allow psychiatric euthanasia and/or assisted suicide (EAS), we argue that potentially effective treatments for suicidal ideation and behaviour, such as ketamine, should be required before allowing patients to access psychiatric EAS. Ketamine can...
bioRxiv : the preprint server for biology
August 4, 2026
Kanchan Sinha Roy, Payton Martinez, Sedona N. Ewbank et al.
preprint
The psychiatric utility of ketamine is limited by its dissociative and systemic side effects. Recently, to enable precision ketamine pharmacotherapy, we introduced SonoKet, ketamine-loaded acoustically activatable liposomes that enable focused ultrasound (FUS)-targeted ketamine delivery to millimeter-sized brain regions. In initial studies, we observed that SonoKet uncaging targeted ketamine to...