Psychopharmacology
August 27, 2026
Shayan Eghdami, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi et al.
Approximately 40-60% of patients with obsessive-compulsive disorder (OCD) fail to respond to standard serotonergic and behavioral therapies. This systematic review evaluates the efficacy, durability, and safety of ketamine, a glutamate modulator, for moderate to severe OCD. Following PRISMA guidelines, we searched electronic databases through January 2026 for studies treating moderate-to-severe...
Journal of Neurophysiology
August 26, 2026
An EEG-Based Evaluation of Antidepressant Effects of Ketamine Enantiomers and Metabolites in Monkeys.
The Journal of Clinical Psychiatry
August 26, 2026
The Prescriber's Guide to Oral Ketamine for Patients With Major Depressive Illness: Principles and Practice.
Frontiers in Psychiatry
August 26, 2026
Jon Berner
Background Multiple preclinical and clinical reports suggest that rapamycin augmentation may increase the safety and efficacy of ketamine treatment. Population variability in patient biochemical gain-of-function and phenotypic admixtures, however, has slowed initial investigations into patient selection and dose finding. Methods A single-center, retrospective chart review identified 101...
Tạp chí Y học Cộng đồng
August 25, 2026
Long Tiến Nguyễn, T. Trần, Cường Mạnh Đặng et al.
Bối cảnh: Ketamine là thuốc gây mê phân ly đang ngày càng bị lạm dụng với mục đích giải trí. Tổn thương đường tiết niệu do ketamine đã được mô tả rộng rãi, tuy nhiên sự hiện diện bất thường tại nhiều cơ quan trên cắt lớp vi tính (CLVT) chưa được báo cáo đầy đủ trong y văn. Ca bệnh: Chúng tôi báo cáo trường hợp bệnh nhân nam 34 tuổi nhập viện vì sốt kéo dài, tiểu lắt nhắt và tăng men gan. Can...
Neuropsychiatrie
August 25, 2026
Nicolas Schmelzle, Katrin Neubacher, Paul L. Plener et al.
BACKGROUND: Depressive symptoms and suicidality are highly prevalent in adolescents with early-onset psychosis (EOP) and often remain refractory to standard treatment. While S‑ketamine is an established treatment for treatment-resistant depression in adults (TRD), its use in primary psychotic disorders remains scarce due to risk of exacerbation of psychotic symptoms. CASE PRESENTATION: We...
The Canadian journal of urology
August 21, 2026
Derrick Tsang, Ioannis Loufopoulos, Konstantinos Kapriniotis et al.
Ketamine is a potent anaesthetic drug that has been used for decades. Ketamine abuse is an increasingly common problem, particularly among young people. Over one quarter of ketamine users will have at least one bothersome urological symptom, with heavier and longer use leading to potentially irreversible damage to the lower and upper urinary tract. Hence, this study carried out a narrative...
Frontiers in Nutrition
August 21, 2026
Agnieszka Mechlińska, Mariusz S. Wiglusz, Jakub Słupski et al.
This study evaluated the acute and short-term effects of repeated ketamine treatment on appetite in adult inpatients with treatment-resistant mood disorders, including major depressive disorder and bipolar disorder. Appetite, hunger, and desire to eat were assessed using the Visual Analog Scales (VAS) and the Simplified Nutritional Appetite Questionnaire (SNAQ) at baseline and at multiple time...
International Immunopharmacology
August 19, 2026
Ali A Albariqi, Dalia A. Nawwar, Weam W Ibrahim et al.
Baricitinib, a selective JAK1/JAK2 inhibitor with established anti-inflammatory properties, has demonstrated therapeutic efficacy in several autoimmune and inflammatory diseases. This study aimed to investigate the neuroprotective potential of baricitinib in a ketamine-induced rat model of schizophrenia. Specifically, the study examined its effects on behavioral deficits, neurochemical...
Translational Psychiatry
August 18, 2026
Marvin Sören Meiering, David Weigner, Matti Gärtner et al.
Rumination has been associated with aberrant dynamics of a coactivation pattern (CAP) comprising the default mode (DMN) and frontoparietal (FPN) networks. Ketamine exerts rapid antidepressant effects and may influence these dynamics via glutamatergic mechanisms. In a randomized, double-blind, placebo-controlled fMRI study, we investigated ketamine's effects on dynamic CAPs associated with...