Psychiatry International
September 1, 2026
Damian Swieczkowski, Michal Pruc, Lukasz Szarpak et al.
Major depressive disorder (MDD) and treatment-resistant depression (TRD) continue to drive interest in ketamine-family compounds and psilocybin, but antidepressant efficacy alone does not establish whether these interventions can be evaluated reliably or implemented responsibly. We conducted a structured narrative review using targeted PubMed/MEDLINE searches through 21 July 2026,...
Medical Science
August 30, 2026
Julia Rogała, Kinga Polityńska, Dominika Ruszel et al.
Treatment-resistant depression occurs in roughly one-third of individuals diagnosed with depression.Ketamine and esketamine have appeared as innovative antidepressant treatments that target the glutamatergic system and deliver promising therapeutic options for patients unresponsive to conventional monoaminergic antidepressants.This review delivers a complete analysis of the mechanisms of...
Neurotoxicology
August 30, 2026
Mola Mohammadi, Amin Saeedi, Ali Asghar Kheirkhah Vakilabad et al.
Ketamine presents a modern pharmacological paradox, acting as both a rapid-acting antidepressant and a drug of abuse with significant cognitive consequences. While its therapeutic potential is revolutionary, chronic exposure is increasingly associated with persistent and specific deficits in episodic and working memory. This narrative review moves beyond descriptive lists of ketamine's effects...
Bipolar Disorders
August 30, 2026
Chih‐Cheng Lin, Lien‐chung Wei
OBJECTIVES: To contextualize the real-world findings of repeated intravenous ketamine infusions for treatment-resistant bipolar depression (TRBPD) and identify priorities for safer, more durable clinical implementation. METHODS: We provide a focused commentary on Zhou et al. (2023) and integrate selected evidence concerning inflammatory and metabolic correlates, neurocognitive outcomes, and...
Neuropsychopharmacology
August 29, 2026
Briana K Chen, Brenna L Williams, Anna Darling et al.
Brain-derived neurotrophic factor (BDNF) exon VI promoter is implicated in mediating activity-induced synthesis of hippocampal BDNF. BDNF is implicated in (R,S)-ketamine's antidepressant effects, but its role in (R,S)-ketamine-mediated prophylaxis is unknown. Using BDNF-e6 mice, in which promoter VI-driven BDNF production is disrupted, we tested its necessity for (R,S)-ketamine's prophylactic...
Psychoanalytic Inquiry
August 28, 2026
Diana Moga
Autistic individuals are more susceptible to trauma due to higher baseline anxiety and overwhelm; poorer episodic memory; and the frequent lack of a sense of community, safety, and belonging that are both protective and needed to heal from trauma. Furthermore, many autistic adults have adopted a false self to get by in a neurotypical world and are often cut off from their affective, embodied...
August 28, 2026
Holly Hepburn
Renewed clinical interest in psychedelics has drawn attention to their challenging effects, yet most phenomenological and psychometric work derives from psilocybin, leaving cross-substance variation underexplored. This thesis employed codebook thematic analysis to examine challenging experiences across DMT, psilocybin, MDMA, and ketamine, utilising 146 naturalistic accounts collected from...
Psychopharmacology
August 27, 2026
Shayan Eghdami, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi et al.
Approximately 40-60% of patients with obsessive-compulsive disorder (OCD) fail to respond to standard serotonergic and behavioral therapies. This systematic review evaluates the efficacy, durability, and safety of ketamine, a glutamate modulator, for moderate to severe OCD. Following PRISMA guidelines, we searched electronic databases through January 2026 for studies treating moderate-to-severe...
Journal of Neurophysiology
August 26, 2026
An EEG-Based Evaluation of Antidepressant Effects of Ketamine Enantiomers and Metabolites in Monkeys.
The Journal of Clinical Psychiatry
August 26, 2026
The Prescriber's Guide to Oral Ketamine for Patients With Major Depressive Illness: Principles and Practice.