Revista Virtual de Química2021Maria Emanuelle Damazio Lima, Isian Santos da Silva, Mariana de Oliveira Leal Desmarais et al.2 citations
Most of the new developed drugs are natural or analogous products, including those that act on the Central Nervous System. The search for new drugs for the treatment of depression is increasing, in view of the high worldwide incidence of this mental disorder. In this context, tryptophan derivatives have an antidepressant effect due to the presence of indole rings, which give them a similarity...
Dataset for a bibliometric analysis of journal articles reporting findings from clinical studies of the psychedelics 5-methoxy-N, N-dimethyltryptamine (5-MeO-DMT), ayahuasca, dimethyltryptamine (DMT), ibogaine, lysergic acid diethylamide (LSD), mescaline, MDMA, and psilocybin published from 1965-2018.This data accompanies our article:Bibliometric Analysis of Academic Journal Articles Reporting...
The Problem of Pain Sophie Pinkham (bio) White Market Drugs: Big Pharma and the Hidden History of Addiction in America by David Herzberg University of Chicago Press, 2020, 400 pp. Click for larger view View full resolution A worker removes the Sackler name from a building at Tufts University in 2019. (David L. Ryan/The Boston Globe via Getty Images) [End Page 130] Reams have been written about...
The psychedelic alkaloid ibogaine has anti-addictive properties in both humans and animals1. Unlike most medications for the treatment of substance use disorders, anecdotal reports suggest that ibogaine has the potential to treat addiction to various substances, including opiates, alcohol and psychostimulants. The effects of ibogaine-like those of other psychedelic compounds-are long-lasting2,...
Background U.S. Special Operations Forces Veterans are at increased risk for a variety of mental health problems and cognitive impairment associated with military service. Current treatments are lacking in effectiveness and adherence. Therefore, this study examined psychedelic treatment with ibogaine and 5-methoxy-N,N-dimethyltryptamine for trauma-related psychological and cognitive impairment...
The serotonin transporter (SERT) belongs to the monoamine transporter family, which also includes the dopamine and norepinephrine transporters. SERT is essential for regulating serotonergic signaling by the reuptake of serotonin from the synaptic cleft back into the presynaptic neuron. Dysregulation of SERT has been implicated in several major psychiatric disorders such as major depressive...
The exploration of possible therapeutic benefits of hallucinogenic substances has undergone a revitalization in the past decade. This literature review investigated the published literature regarding the psychotherapeutic uses of hallucinogens in psychiatric disorders. The results showed that a variety of substances have been evaluated in the treatment of psychiatric disorders, including...
Objective. This article aims to offer a vision of the centers at a global level that use derivatives of plants or animals for the treatment of substance use disorders, and to offer a reflection on the concept of drugs as medicinal or toxicant agents depending on the context of use, culture and policy. Methodology. Some practices coming from Africa, Asia, Europe and the Americas were considered,...
The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatment of depression, anxiety and post-traumatic stress. Here, we apply hydrogen-deuterium exchange...
This chapter aimed to provide an overview of the large number of hallucinogens of natural origin. Following a literature review, the following hallucinogens were selected for a detailed description that considered their essential chemical groups: indoleamines ( N,N -dimethyltryptamine, 5-methoxy- N,N -dimethyltryptamine, bufotenine, psilocybin, and ibogaine), phenylethylamines (mescaline),...