Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies.
Neuropharmacology December 15, 2019 Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning et al. 20 citations
The serotonin transporter (SERT) belongs to the monoamine transporter family, which also includes the dopamine and norepinephrine transporters. SERT is essential for regulating serotonergic signaling by the reuptake of serotonin from the synaptic cleft back into the presynaptic neuron. Dysregulation of SERT has been implicated in several major psychiatric disorders such as major depressive...