Biologie aujourd'hui
2019
Rémi Corne, Raymond Mongeau
7 citations
Psychedelic drugs, often referred to as hallucinogens, are quite distinct from other classes of psychotropic drugs. Although the subjective and behavioral effects they induce are quite dramatic, they possess little addictive potential when compared to nicotine, alcohol or opiates. Since the discovery of ketamine antidepressant effects, there has been growing interest for these molecules....
Frontiers in Pharmacology
July 5, 2018
Eduardo Ekman Schenberg
242 citations
Mental disorders are rising while development of novel psychiatric medications is declining. This stall in innovation has also been linked with intense debates on the current diagnostics and explanations for mental disorders, together constituting a paradigmatic crisis. A radical innovation is psychedelic-assisted psychotherapy (PAP): professionally supervised use of ketamine, MDMA, psilocybin,...
Australian & New Zealand Journal of Psychiatry
September 28, 2016
N. Strauss, Stephen Bright, Martin L Williams
10 citations
Australian & New Zealand Journal of Psychiatry, 50(11) A recent review in Pharmacological Reviews highlights that over the last decade, a renaissance has occurred in psychedelic drug research in North America and Europe as investigators at Johns Hopkins School of Medicine, University of California, Los Angeles (UCLA), New York University and Imperial College London have embarked on studies that...
PLoS One
June 14, 2016
Heidi Koldsø, Henriette Elisabeth Autzen, Julie Grouleff et al.
The competitive inhibitor cocaine and the non-competitive inhibitor ibogaine induce different conformational states of the human serotonin transporter. It has been shown from accessibility experiments that cocaine mainly induces an outward-facing conformation, while the non-competitive inhibitor ibogaine, and its active metabolite noribogaine, have been proposed to induce an inward-facing...
March 8, 2016
Ben Sessa, Eileen Worthley
1 citation
Psychedelic Drug Treatments: Assisting the Therapeutic Process provides information about current and quite viable investigation into reviving and progressing with neurological research that began in the middle of the 20th century and was brought to a halt when certain drugs were banned in the 1970s. Using a question/answer format, the book will introduce you to the way in which the chemical...
Pharmacology, Biochemistry, and Behavior
2016
Amir H Rezvani, Marty C Cauley, Susan Slade et al.
22 citations
The ibogaine derivative 18-methoxycoronaridine (18-MC) has been found to decrease self-administration of morphine, nicotine and alcohol in rats after systemic injection. However oral dosing is the preferred route clinically. The current study evaluated the effect of oral 18-MC dosing in rats on alcohol and nicotine self-administration. For the nicotine study, young adult female Sprague-Dawley...
Journal of Anatomical Society of India
September 1, 2015
Biju Urumese Pallatty, Asha Joselet Mathew, T.s. Tintu
Food is medicine and vice versa. In Hindu and Ayurvedic medicine, and among human cultures of the Indian subcontinent in general, the perception of the food-medicine continuum is especially well established. The preparation of the exhilarating, gold-coloured Soma, Amrita or Ambrosia, the elixir and food of the 'immortals'–the Hindu pantheon–by the ancient Indo-Aryans, is described in the...
Open Mind
2015
Jonathan Cachat, Chris Collins, Evan J. Kyzar et al.
preprint
Three-dimensional reconstructions of zebrafish swimming paths (Cachat et al. 2011) are a new technique to discover novel, meaningful behavioral patterns evoked by different experimental manipulations. Compared to traditional 2D traces, 3D swim path reconstructions enable both macro-level (general) and micro-level (specific/repeated) analyses of potentially meaningful behavioral patterns,...
The British Journal of Psychiatry
2015
Ben Sessa, Matthew W. Johnson
58 citations
Summary After a 40-year hiatus there is now a revisiting of psychedelic drug therapy throughout psychiatry, with studies examining the drugs psilocybin, ketamine, ibogaine and ayahuasca in the treatment of drug dependence. Limitations to these therapies are both clinical and legal, but the possibility of improving outcomes for patients with substance dependency imposes an obligation to research...
Journal of Ethnopharmacology
August 8, 2014
Marco Leonti, Laura Casu
15 citations
Food is medicine and vice versa. In Hindu and Ayurvedic medicine, and among human cultures of the Indian subcontinent in general, the perception of the food-medicine continuum is especially well established. The preparation of the exhilarating, gold-coloured Soma, Amrita or Ambrosia, the elixir and food of the 'immortals'-the Hindu pantheon-by the ancient Indo-Aryans, is described in the...