Marika Slivacka

Conformational dynamics of the human serotonin transporter during substrate and drug binding.

Nature Communications April 11, 2019 Ingvar R Möller, Marika Slivacka, Anne Kathrine Nielsen et al. 92 citations

The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatment of depression, anxiety and post-traumatic stress. Here, we apply hydrogen-deuterium exchange...