Ibogaine: all studies (page 26) - The Consciousness Library

Ibogaine may help drug addicts live the 'never again'.

South African Medical Journal July 1, 2006

Ibogaine may help drug addicts live the 'never again'.

Fatalities after taking ibogaine in addiction treatment could be related to sudden cardiac death caused by autonomic dysfunction.

Medical Hypotheses 2006 U Maas, S Strubelt 41 citations

Ibogaine is the most important alkaloid of the Central African Iboga-shrub. It is the central drug in Gabonian initiation ceremonies in which it is used to cause a near-death experience. In Western countries it is used in private clinics to treat addiction. However, in the United States and most European countries it is classified as an illegal drug because at least eight persons have died...

DOI: 10.1016/j.mehy.2006.02.050 Full text Psychedelic Hallucinogen Cardiovascular risk Heart arrhythmia +18

Ibogaine reduces organ colonization in murine systemic and gastrointestinal Candida albicans infections.

Journal of medical microbiology July 1, 2005 M Yordanov, P Dimitrova, S Patkar et al. 19 citations

In the present study the effect of the indole alkaloid ibogaine on the in vitro lipolytic activity and adherence to epithelial cells of Candida albicans was investigated. The substance was administered intraperitoneally at a dose of 5 mg kg(-1) day(-1) in mice with disseminated and gastrointestinal C. albicans infections. Ibogaine significantly decreased the rate of mortality and the number of...

DOI: 10.1099/jmm.0.45919-0 Full text Ibogaine Fungal infections Antifungal treatment Combination therapy

Ibogaine Therapy: A 'Vast, Uncontrolled Experiment'

Science April 14, 2005 Brian Vastag 38 citations

Despite potentially harsh side effects, an African plant extract is being tested in two public clinical trials--and many clandestine ones.

DOI: 10.1126/science.308.5720.345 Clinical trial

Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption

Journal of Neuroscience January 19, 2005 Dao‐yao He, Nancy N. H. Mcgough, Ajay Ravindranathan et al. 181 citations

Alcohol addiction manifests as uncontrolled drinking despite negative consequences. Few medications are available to treat the disorder. Anecdotal reports suggest that ibogaine, a natural alkaloid, reverses behaviors associated with addiction including alcoholism; however, because of side effects, ibogaine is not used clinically. In this study, we first characterized the actions of ibogaine on...

DOI: 10.1523/jneurosci.3959-04.2005 Full text Ventral tegmental area Neurotrophic factors Pharmacology Self-administration +3

Ibogaine ‐ poison or panacea?

Drugs and Alcohol Today November 1, 2004 Gary Hayes

Ibogaine is hailed as a miracle cure for addictions, with reports of up to 90% effectiveness, while others talk of violent reactions and an increased potential of overdose. In this overview, we look at its potential as a treatment for addictions. We talk to those who administer it and use it and ask why so little research has been carried out in the UK to establish its safety and uncover...

DOI: 10.1108/17459265200400033 Addiction Panacea medicine Miracle Criminology +2

Combating substance abuse with ibogaine: pre- and posttreatment recommendations and an example of successive model fitting analyses.

Journal of Psychoactive Drugs June 1, 2004 James B Hittner, Susan B Quello 3 citations

Ibogaine is an indole alkaloid derived from the root bark of the African shrub Tabernan the iboga and it has been used for many years as a medicinal and ceremonial agent in West Central Africa. Furthermore, both anecdotal observations and recent studies suggest that ibogaine alleviates withdrawal symptoms and reduces drug cravings. Although ibogaine articles typically include information...

DOI: 10.1080/02791072.2004.10399729 Full text Ibogaine natural compound African shrub Cravings Substance abuse +7

Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration.

European Journal of Pharmacology May 1, 2004 Christopher J Pace, Stanley D Glick, Isabelle M Maisonneuve et al.

18-Methoxycoronaridine, a novel iboga alkaloid congener, reduces drug self-administration in animal models of addiction. Previously, we proposed that these effects are mediated by the ability of 18-methoxycoronaridine to inhibit nicotinic alpha3beta4 acetylcholine receptors. In an attempt to identify more potent 18-methoxycoronaridine analogs, we have tested a series of 18-methoxycoronaridine...

DOI: 10.1016/j.ejphar.2004.03.062 Full text Ibogaine Cell line Animals Humans +12

Differential effects of ibogaine on local cerebral glucose utilization in drug-naive and morphine-dependent rats.

Brain Research April 2, 2004 Beth Levant, Thomas L Pazdernik 17 citations

Ibogaine, a hallucinogenic indole alkaloid, has been proposed as a treatment for addiction to opioids and other drugs of abuse. The mechanism for its putative anti-addictive effects is unknown. In this study, the effects of ibogaine on local cerebral glucose utilization (LCGU) were determined in freely moving, drug-naive, or morphine-dependent adult, male, Sprague-Dawley rats using the...

DOI: 10.1016/j.brainres.2003.12.032 Full text Ibogaine plant-derived compound Therapeutic applications Reward and addiction Brain energy use +3

Administration of a non-NMDA antagonist, GYKI 52466, increases excitotoxic Purkinje cell degeneration caused by ibogaine.

Neuroscience 2004 E O'Hearn, M E Molliver 16 citations

Ibogaine is a tremorigenic hallucinogen that has been proposed for clinical use in treating addiction. We previously reported that ibogaine, administered systemically, produces degeneration of a subset of Purkinje cells in the cerebellum, primarily within the vermis. Ablation of the inferior olive affords protection against ibogaine-induced neurotoxicity leading to the interpretation that...

DOI: 10.1016/j.neuroscience.2004.04.058 Full text Neurotoxicity Nerve cell damage Brain cell damage Neurodegeneration +16