Ibogaine reduces organ colonization in murine systemic and gastrointestinal Candida albicans infections.
Journal of medical microbiology July 1, 2005 M Yordanov, P Dimitrova, S Patkar et al. 19 citations
The indole alkaloid ibogaine reduced mortality and fungal burden in the kidney, liver, and spleen of mice with disseminated and gastrointestinal Candida albicans infections when given intraperitoneally at 5 mg/kg/day. Ibogaine interfered with early infection stages but did not lower fungal counts during late infection. It did not alter specific immune responses, as delayed-type hypersensitivity and interferon-gamma production were similar between treated and control mice. Combining ibogaine with amphotericin B reduced organ colonization more effectively than either treatment alone.