Iboga's Travel is the title of a global project which was conceived after a Gabonese initiation into ‘Bwiti’. The Bwiti is one of the few secret shamanic practices forced to open itself to the outside world by the disappearance of the Equatorial forest. Its traditions remain alive in Gabon, but it has to adapt to the changes brought by cultural globalization. The Bwiti is a rite in which the...
Ibogaine (IBO) is an alkaloid with putative antiaddictive properties, alleviating opiates dependence and withdrawal. The glutamate N-methyl-D-aspartate (NMDA) receptors have been implicated in the physiological basis of drug addiction; accordingly, IBO acts as a noncompetitive NMDA antagonist. The purpose of this study was to evaluate the effects of IBO on naloxone-induced withdrawal syndrome...
18-Methoxycoronaridine (18-MC), a novel iboga alkaloid congener that decreases drug self-administration in several animal models, may be a potential treatment for multiple forms of drug abuse. In animal models, 18-MC reduced intravenous morphine, cocaine, methamphetamine and nicotine self-administration, oral alcohol and nicotine intake, and attenuated signs of opioid withdrawal, but had no...
Synthesis of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated.
Ibogaine is a naturally occurring indole alkaloid, found in a variety of African shrubsof the Tabernathe genus (Obach, Pablo, and Mash, 1998). The root of the Tabernathe ibogaplant (also known as eboga) is the most frequently cited source of ibogaine, and this plantcontains 11 other known psychoactive constituents (Popik, and Skolnick, 1999). Chemically,ibogaine is classified as a tryptamine,...
Chemical dependency continues to be a major public health problem. Current approaches to treating addictive disorders have not shown high rates of efficacy , and it is therefore vital that novel methods of therapy be explored and developed. lbogaine is a naturally occurring compound that is currently being studied for use in the treatment of a variety of substance addictions , including opiate...
18-Methoxycoronaridine, a newly developed ibogaine analog, has been reported to decrease the self-administration of morphine, cocaine, ethanol, and nicotine. It has also been reported to attenuate naltrexone-precipitated signs of morphine withdrawal. In this study, three metabolites of 18-methoxycoronaridine (18-MC) were separated and identified by high-performance liquid...
The mapping of the human genetic code will enable us to identify potential gene products involved in human addictions and diseases that have hereditary components. Thus, large-scale, parallel gene-expression studies, made possible by advances in microarray technologies, have shown insights into the connection between specific genes, or sets of genes, and human diseases. The compulsive use of...
1. The molecular nature and functions of the I(2) subtype of imidazoline binding sites are unknown but evidence suggests an association with monoamine oxidase (MAO). Rats can distinguish the selective imidazoline I(2)-site ligand 2-BFI from vehicle in drug discrimination, indicating functional consequences of occupation of these sites. We have used drug discrimination to investigate the nature...
It has been reported that ibogaine interferes with somatic withdrawal reactions in rats chronically treated with morphine. The present experiments demonstrated that ibogaine also interferes with motivational withdrawal reactions and somatic withdrawal reactions in rats treated with morphine on only two occasions. On each of two conditioning trials, naloxone was administered 24 h following an...