Despite considerable efforts, tobacco use disorder persists as a significant public health issue. The effectiveness of current smoking cessation therapies is limited, leading to a growing interest in alternative treatment approaches such as psychedelics. The aim of this review is to evaluate the scientific evidence regarding the role of psychedelics in smoking cessation. To identify relevant...
The recent relaxation of psychedelic drug regulations has prompted extensive clinical investigation into their potential use to treat diverse mental health conditions including anxiety, depression, post-traumatic stress, and substance-abuse disorders. Most clinical trials have relied on a small number of known molecules found in nature, such as psilocybin, or long-known synthetic analogs of...
Abstract A recent wave of research in psychiatry and neuroscience has re-examined the properties of ‘classic’ psychedelic substances—also known as serotonergic hallucinogens—such as psilocybin, lysergic acid diethylamide (LSD), and N,N-dimethyltryptamine (DMT). Evidence to date suggests that psychedelics can be given safely in controlled conditions, at moderate to high doses, and may have...
Emerging evidence suggests that classical psychedelics possess immunomodulatory and anti-inflammatory properties; however, these effects are yet to be well-established. This systematic review aims to provide a timely and comprehensive overview of the immunomodulatory effects of classical psychedelics in preclinical studies. A systematic search was conducted on six databases, including CINAHL,...
Importance A clear and comprehensive understanding of risks associated with psychedelic-assisted therapy is necessary as investigators extend its application to new populations and indications. Objective To assess adverse events (AEs) associated with classic psychedelics, particularly serious AEs (SAEs) and nonserious AEs (NSAEs) requiring medical or psychiatric evaluation. Data Sources The...
This article provides an intercultural transdisciplinary perspective on the Indigenous roots of the resurging field of psychedelic science in the management of substance use disorders (SUDs). Ritual uses of entheogens (i.e., psychedelics of natural origin) are elaborate technologies for navigating, containing, and therapeutically directing non-ordinary states of consciousness induced by these...
Psychedelics have been used therapeutically for thousands of years by various cultures, and the term "novel therapeutic agent" should not describe them. The classic psychedelics are mainly tryptamines (e.g., psilocybin, DMT, LSD) and phenethylamines (e.g., MDMA, mescaline, 2C-B), with tryptamines being more studied currently. While most psychedelics are medically safe, some like ibogaine and...
Smartphones have become everyday objects on which the accumulation of fingerprints is significant. In addition, a large proportion of the population regularly uses a smartphone, especially younger people. The objective of this study was to evaluate smartphones as a new matrix for toxico-epidemiology. This study was conducted during two separate events (techno and trance) at an electronic music...
Abstract Background Psychedelic use and its impact on well-being is garnering a lot of research attention, however, little has been done to understand the potential associations between multiple characteristics of the psychedelic experience and psychological flexibility (PF), which encompasses a conscious awareness of thoughts and behavior, allowing individuals to adapt to new experiences and...
N, N-dimethyltryptamine (DMT) is a psychedelic tryptamine acting on 5-HT2A serotonin receptors, which is associated with intense visual hallucinatory phenomena and perceptual changes such as distortions in visual space. The neural underpinnings of these effects remain unknown. We hypothesised that changes in population receptive field (pRF) properties in the primary visual cortex (V1) might...