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The British Journal of Psychiatry November 1, 2005 G. Edwards
Grof (1975Grof ( , 1990) ) has been the most Grof (1975Grof ( , 1990) ) has been the most prominent explorer of these inaccessible prominent explorer of these inaccessible regions for over 40 years and once research regions for over 40 years and once research into lysergic acid diethylamide (LSD) into lysergic acid diethylamide (LSD) became impossible, developed a technique became impossible,...
Pharmacopsychiatry September 1, 2005 Euphrosyne Gouzoulis‐mayfrank, Karsten Heekeren, Anna Neukirch et al.
Patients with schizophrenia exhibit disturbances of orienting of attention. However, findings have been inconsistent. Hallucinogen challenges have been used as models for psychosis. The NMDA antagonist state resembles undifferentiated psychoses, whereas the 5-HT2A agonist state is considered as a model for psychoses with prominent positive symptoms. The aim of this study was to investigate...
Bioorganic & Medicinal Chemistry Letters August 3, 2005 Howard Sard, Govindaraj Kumaran, Cynthia Morency et al. 78 citations
An SAR study of psilocybin and psilocin derivatives reveals that 1-methylpsilocin is a selective agonist at the h5-HT(2C) receptor. The corresponding phosphate derivative, 1-methylpsilocybin, shows efficacy in an animal model for obsessive-compulsive disorder, as does 4-fluoro-N,N-dimethyltryptamine. These results suggest a new area for development of novel 5-HT(2C) agonists with applications...
European Journal of Pharmacology July 11, 2005 Kinzo Matsumoto, Ryo Morishige, Yukihisa Murakami et al.
Isorhynchophylline is a major oxindole alkaloid found in Uncaria species which have long been used in traditional Chinese medicine. Here, we investigated the effects of isorhynchophylline and isorhynchophylline-related alkaloids on 5-hydroxytryptamine (5-HT) receptor-mediated behavioural responses in mice and 5-HT-evoked current responses in Xenopus oocytes expressing 5-HT2A or 5-HT2C...
Journal of Psychoactive Drugs June 1, 2005 James C. Callaway, Glacus S. Brito, Edison S. Neves
A total of 32 Banisteriopsis caapi samples and 36 samples of Psychotria viridis were carefully collected from different plants on the same day from 22 sites throughout Brazil for phytochemical analyses. A broad range in alkaloid distribution was observed in both sample sets. All B. caapi samples had detectable amounts of harmine, harmaline and tetrahydroharmine (THH), while some samples of P....
Journal of Psychoactive Drugs June 1, 2005 James C. Callaway
Twenty nine decoctions of Banisteriopsis caapi from four different sources and one specimen of B. caapi paste were analyzed for N,N-dimethyltryptamine (DMT), tetrahydroharmine (THH), harmaline and harmine. Other plants were also used in the preparation of these products, typically Psychotria viridis, which provides DMT. There were considerable variations in alkaloid profiles, both within and...
The British Journal of Psychiatry June 1, 2005 Ben Sessa 97 citations
Psychedelic or hallucinogenic drugs such as lysergic acid diethylamide (LSD), 3, 4, 5-trimethoxy-β-phenethylamine (mescaline), psilocybin, 3, 4-methylenedioxymethamph-etamine (MDMA), N, N-dimethyltrypta-mine (DMT) and their relations occur in abundance throughout the natural world, and have been used by humankind for thousands of years.
Neuropsychopharmacology January 26, 2005 Olivia Carter, John D. Pettigrew, Felix Hasler et al. 122 citations
Binocular rivalry occurs when different images are presented simultaneously to corresponding points within the left and right eyes. Under these conditions, the observer's perception will alternate between the two perceptual alternatives. Motivated by the reported link between the rate of perceptual alternations, symptoms of psychosis and an incidental observation that the rhythmicity of...
Digital Creativity 2005 Diana Slattery 4 citations
Abstract The literatures that touch on synaesthesias-scientific, art-historical, literary, phenomenological, ethnographic, psychodelic-vary widely in their definitions, their interpretations, and their degree of comfort with the first-person, subjective nature of experiential reports. The significances given to synaesthetic experiences are similarly wide-ranging. This paper explores the...
University of Toronto quarterly December 1, 2004 John V. Walker
Reviewed by: In the Houses of the Holy: Led Zeppelin and the Power of Rock Music John V. Walker (bio) Susan Fast. In the Houses of the Holy: Led Zeppelin and the Power of Rock Music Oxford University Press 2001. vii, 248. $22.00 The prologue of Marcus Boon's The Road of Excess: A History of Writers on Drugs, aside from violating the unwritten law that the PhD candidate's tortuous attempt to...