International Journal of Drug Policy
December 5, 2006
Kenneth W. Tupper
207 citations
Ayahuasca is a tea made from two plants native to the Amazon, Banisteriopsis caapi and Psychotria viridis, which, respectively, contain the psychoactive chemicals harmala alkaloids and dimethyltryptamine. The tea has been used by indigenous peoples in countries such as Brazil, Ecuador and Peru for medicinal, spiritual and cultural purposes since pre-Columbian times. In the 20th century,...
Journal of Psychopharmacology
May 20, 2006
Marc Wittmann, Olivia Carter, Felix Hasler et al.
245 citations
Hallucinogenic psilocybin is known to alter the subjective experience of time. However, there is no study that systematically investigated objective measures of time perception under psilocybin. Therefore, we studied dose-dependent effects of the serotonin (5-HT) 2A/1A receptor agonist psilocybin (4-phosphoryloxy-N, N-dimethyltryptamine) on temporal processing, employing tasks of temporal...
Psychopharmacology
March 30, 2006
Jordi Riba, Sergio Romero, Eva Grasa et al.
245 citations
RationaleAyahuasca is a South American psychoactive plant tea which contains the serotonergic psychedelic N,N-dimethyltryptamine (DMT) and monoamine-oxidase inhibitors that render DMT orally active. Previous investigations with ayahuasca have highlighted a psychotropic effect profile characterized by enhanced introspective attention, with individuals reporting altered somatic perceptions and...
The FASEB Journal
March 1, 2006
Michael R Braden, James J. Chambers, David E. Nichols
The human serotonin 2A receptor (h5‐HT 2A R) plays an essential role in cognition, and is the principal target for serotonergic hallucinogens as well as atypical antipsychotics. Utilizing our in silico ‐activated h5‐HT 2A R homology model, an interaction was predicted between Asn343(6.55) in TM6 and the carbonyl of LSD. Virtual docking simulations of a new class of 5‐HT2 agonists, substituted N...
Neuropsychopharmacology
February 2006
Euphrosyne Gouzoulis‐mayfrank, Karsten Heekeren, Anna Neukirch et al.
Patients with schizophrenia exhibit disturbances of orienting of attention. However, findings have been inconsistent. Pharmacologic challenges with hallucinogens have been used as models for psychosis. The NMDA antagonist state (PCP, ketamine) resembles undifferentiated psychoses with positive and negative symptoms, while the 5-HT(2A) agonist state (LSD, dimethyltryptamine (DMT)) is thought to...
The pharmacogenomics journal
2006
M A Davies, Vincent Setola, R T Strachan et al.
The 5-HT(2A)-serotonin receptor is a major molecular target for most atypical antipsychotic drugs as well as most hallucinogens, which can exacerbate psychotic symptoms. In this study, we examined whether random sequence variations in the gene (single nucleotide polymorphisms, SNPs) encoding the 5-HT(2A)-serotonin receptor could explain inter-individual variability in atypical antipsychotic and...
Pharmacology, Biochemistry, and Behavior
2006
William E Fantegrossi, A W Harrington, C L Kiessel et al.
144 citations
Few studies have examined the effects of 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) in vivo. In these studies, 5-MeO-DIPT was tested in a drug-elicited head twitch assay in mice where it was compared to the structurally similar hallucinogen N,N-dimethyltryptamine (N,N-DMT) and challenged with the selective serotonin (5-HT)2A antagonist M100907, and in a lysergic acid diethylamide (LSD)...
Discourse
December 1, 2005
Richard Doyle
7 citations
Twenty minutes in, like clockwork, the visions begin. They are strong but I was expecting them this time. Norma, the vegetalista who so astonished me with her care, skill and knowledge during my first ceremony two nights prior, had packed a big bowl with a knot of the local Nicotina Rustica and had blown curling, whistling smoke over a plastic liter bottle filled with an opaque orangish liquid...
BMJ
November 24, 2005
Samson S. Y. Wong, Kwok‐Yung Yuen
2 citations
Abstract 5-Methoxy-N,N-dimethyltryptamine (acronymized as 5-MeO-DMT) is sui generis among the numerous naturally-occurring psychoactive substances due to its unparalleled ego-dissolving effects which can culminate in a state of nondual consciousness (which is phenomenologically similar to transformative peak experiences described in various ancient contemplative traditions, e.g., Advaita...
The British Journal of Psychiatry
November 1, 2005
B. Sessa
Grof (1975Grof ( , 1990) ) has been the most Grof (1975Grof ( , 1990) ) has been the most prominent explorer of these inaccessible prominent explorer of these inaccessible regions for over 40 years and once research regions for over 40 years and once research into lysergic acid diethylamide (LSD) into lysergic acid diethylamide (LSD) became impossible, developed a technique became impossible,...