SAR of Psilocybin Analogues: Discovery of a Selective 5‐HT2C Agonist.
ChemInform December 13, 2005 Howard Sard, Govindaraj Kumaran, Cynthia Morency et al.
Abstract For Abstract see ChemInform Abstract in Full Text.
Howard Sard
2 papers in the library · 78 citations · publishing 2005
Papers
SAR of psilocybin analogs: Discovery of a selective 5-HT2C agonist
Bioorganic & Medicinal Chemistry Letters August 3, 2005 Howard Sard, Govindaraj Kumaran, Cynthia Morency et al. 78 citations
An SAR study of psilocybin and psilocin derivatives reveals that 1-methylpsilocin is a selective agonist at the h5-HT(2C) receptor. The corresponding phosphate derivative, 1-methylpsilocybin, shows efficacy in an animal model for obsessive-compulsive disorder, as does 4-fluoro-N,N-dimethyltryptamine. These results suggest a new area for development of novel 5-HT(2C) agonists with applications...