Background and Objectives: PolDrugs is the largest Polish naturalistic nationwide survey to present basic demographic and epidemiological data that could potentially prevent harm from illicit substances intake in drugs users. The most recent results were presented in 2021. The goal of this year’s edition was to re-present the above data and compare it to the previous edition’s data to identify...
Data mining and knowledge discovery is a research area with applications in various fields, such as medicine. Data mining methods have proven to be very effective in making automated diagnoses and help medical teams in decision making. In addition to using data mining, medical data can be represented by complex networks. In the case of the brain, for example, brain regions can be represented as...
Mystical and even ego-dissolution experiences can be elicited from entheogens, like sacred potions of ayahuasca and jurema. Although composed of dimethyltryptamine (DMT) and having met at a historical moment, ayahuasca and jurema have different rituals, symbolic references, and origins. This article aims to describe ayahuasca and jurema rituals, in psychometric measures of mysticism and...
Emil Kraepelin believed that dementia praecox, the disorder we now call schizophrenia, was caused by the brain being poisoned with toxins generated in other parts of the body, especially the mouth, intestine or genitals. In this regard, Kraepelin hinted at the microbiome and conceptualized microbial molecules as drivers of severe psychiatric illness. However, it was not until the coronavirus...
Background: Ayahuasca is a serotoninergic hallucinogen that plays a central role in the Amazonian traditional medicine. Its psychoactive effects are associated with the presence of N,N-dimethyltryptamine (DMT), and monoamine oxidase inhibitors (MAO-A). Advances in neuroimaging investigations have provided insight into ayahuasca’s neurobiological mechanisms of action. Methods: Selecting only...
Ayahuasca is a plant-based brew of indigenous Amazonian origin. It has psychedelic, anti-inflammatory, neuroprotective, cytotoxic, and anti-parasitic effects, which are primarily due to monoamine oxidase inhibitors (MAOIs) and N,N-dimethyltryptamine (DMT). This article describes the case of a woman in her late thirties with complex trauma due to severe, years-long sexual abuse in early...
Abstract Psychedelic indolethylamines have emerged as potential medicines to treat several psychiatric pathologies. Natural sources of these compounds include ‘magic mushrooms’, plants used to prepare ahayuasca, and toads. Owing to the occurrence of indolethylamines such as N,N-dimethyltryptamine, toad skin and parotid gland preparations have a history of ceremonial use, yet their biosynthesis...
European PsychiatryMarch 1, 2023E. Prades, A. Torres, P. Díez et al.1 citation
Introduction Ayahuasca is a traditional brew containing the psychedelic 5-DMT (a tryptamine that acts as a 5HT2A-R agonist) used to achieve non-ordinary states of consciousness, with a long tradition among various cultures in ritual and therapeutic contexts. Ayahuasca is being studied as potential treatment in Mental Health, which has led to non-controlled and recreational use. This has led to...
Abstract Ayahuasca is a psychedelic plant brew originating in the Amazon basin. It is typically made from two basic components: the ayahuasca vine (Banisteriopsis caapi), containing various harmala alkaloids, and the leaves of a plant containing the potent psychedelic dimethyltryptamine (DMT), such as the chacruna plant (Psychotria viridis). Evidence suggests the brew has been used for at least...
February 27, 2023Amar Dhall, Torsten Wiedemann, Manav Satija1 citation
The legal framework that regulates ayahuasca in Australia has federal, state, and territory dimensions. This chapter will tease out the complex relationships that exist between various agencies and legislation across these jurisdictions to make plain the state of ayahuasca regulation in 2018. A brief review of unsanctioned ayahuasca use is provided, outlining the implications of imported,...