Mental Health Weekly
November 13, 2023
Valerie A. Canady
Observing that ketamine infusion therapy is increasingly being used for such mental health conditions as major depressive disorder, bipolar disorder, treatment‐resistant depression, and post‐traumatic stress disorder, two national nursing associations have released a joint statement indicating that patients with psychiatric disorders may benefit from the use of ketamine infusion therapy.
Pharmacology, Biochemistry, and Behavior
November 8, 2023
Aida A.C. Brandão, D. L. S. Deus, L. A. Duarte-Filho et al.
Major depressive disorder (MDD) is a debilitating illness that affects millions of people worldwide. Currently available antidepressants often take weeks to months to reach their full effect, which leads to an increased risk of suicidal behavior in patients with MMD. Intranasally, esketamine has emerged as an alternative to current antidepressants because of its rapid onset and long-lasting...
npj Mental Health Research
November 8, 2023
Omer A. Syed, Benjamin Tsang
4 citations
The recent years have seen an unprecedented surge of psychedelic research. Studies with psilocybin (colloquially known as magic mushrooms), in particular, have shown promise in ameliorating symptoms of treatment-refractory depression, anxiety, and substance use disorder, among others 1 , 2 . Microdosing, the practice of regularly taking roughly a tenth of full psychedelic doses, is becoming...
JAPhA Practice Innovations
November 8, 2023
Elizabeth Sugiarto, Rebecca Leung, Jamie Yuen
1 citation
AbstractBackground Psilocybin is the main psychoactive component of a naturally occurring psychedelic organism commonly referred to as "magic mushrooms." Existing literature demonstrates beneficial neurologic effects in treatment-resistant depression, cancer-associated depression and anxiety, and substance use. The evidence base for psilocybin use is on the rise with the U.S. Food and Drug...
Healthcare
November 8, 2023
Anna Wilson, Clare Mckeaveney, Claire Carswell et al.
5 citations
Kidney disease is a progressive, debilitating condition. Patients experience challenging physical and psychological symptoms and are at increased risk of anxiety, depression, and poor mental wellbeing. Access to specialist psychological or social support is limited, with inadequate provision of psychosocial support available across UK renal units. The COSMIC study (examining the acceptability...
Journal of Neuroscience
November 8, 2023
Lindsay P. Cameron, Joseph Benetatos, Vern Lewis et al.
88 citations
Serotonergic psychedelics, such as psilocybin and LSD, have garnered significant attention in recent years for their potential therapeutic effects and unique mechanisms of action. These compounds exert their primary effects through activating serotonin 5-HT2A receptors, found predominantly in cortical regions. By interacting with these receptors, serotonergic psychedelics induce alterations in...
PsyArXiv
November 7, 2023
Mika Turkia
2 citations
preprint
Following advice received in a dream, a woman in her early thirties, suffering from depression, anxiety, and sleep disorders caused by complex trauma in her childhood, experimented with 'microdosing' or psycholytic dosing of Amanita muscaria (fly agaric) mushrooms. During a 3.5-month period with an intuition-based, gradually declining dosing scheme, her symptoms significantly decreased. No...
bioRxiv Preprint Server
November 7, 2023
Kelly E. Dunham, Kani H. Khaled, Leah Weizman et al.
preprint
Recently, the FDA approved microdosing ketamine for treatment resistant depression. Traditional antidepressants, like serotonin selective reuptake inhibitors (SSRIs), block serotonin reuptake, but it is not clear if ketamine blocks serotonin reuptake. Here, we tested the effects of feeding ketamine and SSRIs to Drosophila melanogaster larvae, which has a similar serotonin system to mammals, and...
Citra Delima Scientific journal of Citra Internasional Institute
November 6, 2023
Ady Irawan Am, Anjani Janmabhumi, Ziara Arum Wulandari et al.
Hypertension, a prevalent and chronic medical condition, is often associated with elevated anxiety levels, contributing to its progression and complications. Mindfulness-Based Cognitive Therapy (MBCT) has emerged as a potential intervention to address both anxiety and hypertension. This scoping review aims to explore the existing literature on the effect of MBCT on anxiety and blood pressure in...
IBRO Neuroscience Reports
November 6, 2023
Tomáš Páleníček, Tereza Klučková, Marek Nikolič et al.
INTRODUCTION: The mechanisms by which the psychedelic drug psilocybin, a novel rapid-acting antidepressant, improves depressive symptoms are still unclear. One candidate mechanism is the impact of the phenomenology of the psychedelic experience, with positive phenomenology hypothesised to be associated with positive long-term outcomes and fearful phenomenology hypothesised to be associated with...