Abstract Background The psychedelic psilocybin has been posited as efficacious for the treatment of depression. However, the potential link between the intensity of acute psychedelic effects and long-term therapeutic outcomes remains undiscovered. Moreover, the impact of classical antidepressant drugs that modulate serotonergic activity on psilocybin’s effects is a clinically relevant concern....
Psychedelics show promise in treating depression, PTSD, and substance use disorder, prompting research into their mechanisms of action. Most studies use rodent models, but genetic tools can be challenging to apply. Invertebrate models, like C. elegans , offer a cost-effective alternative with short generation times and genetic tractability. This study examined the worm's response to the...
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s. However, these drugs are now experiencing a renaissance in the field of psychiatry based on increasing evidence that...
Abstract Nightmare disorder is a rapid-eye-movement (REM) parasomnia provoking disturbing oneiric activity and significant distress. This chapter provides a comprehensive overview of the diagnostic criteria and definition of this sleep disorder. The authors reviewed findings on neural correlates of nightmares, also examining the changes over the life span. They describe the most common comorbid...
O uso terapêutico de psicodélicos tem ganhado crescente interesse na psiquiatria, principalmente no tratamento de transtornos mentais resistentes a terapias convencionais, como a depressão resistente e a ansiedade. Este artigo de revisão aborda os fundamentos bioquímicos, a segurança e as indicações emergentes de psicodélicos, como ayahuasca, DMT, psilocibina e LSD, com foco nos mecanismos...
Tecnología en MarchaMay 20, 2025Frank Barrientos-Alfaro, Valeria Herrera-Rojas, Michelle Montero-Quesada et al.
Los hongos juegan un papel clave en el mantenimiento de la vida en la tierra, ya que desempeñan múltiples funciones a nivel ecológico. Adicionalmente, son productores de diversos metabolitos secundarios, entre estos, los alcaloides, los cuales en ciertos casos pueden proveer propiedades alucinógenas. Psilocybe cubensis es una especie común de hongos alucinógenos conocida como “hongos mágicos”....
Adolescents face increasing psychological stressors that demand preventive and therapeutic strategies rooted in both scientific and cultural sensitivity. This review synthesizes findings on the implementation of mindfulness-based interventions (MBIs)—such as Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT)—in secondary education settings, particularly...
Pursuit of happiness (Sukha) has been the universal endeavor of mankind which is rooted in the state of mental wellbeing. Common mental health conditions like anxiety, fear, obsession, irrational behavior, depression, hostility are stumbling blocks in achieving mental well -being and are commonly neglected. India stands at low rank in global happiness index in spite of having a rich heritage of...
This letter discusses the study by Liu et al recently published in World Journal of Psychiatry, which examines the benefits of combining epirubicin (EPI) with mindfulness interventions for patients with urinary system tumors and depression. The study included 110 patients and compared an experimental group receiving EPI and a mindfulness intervention strategy with a control group treated with...
Introduction: Electroconvulsive therapy (ECT) is an effective treatment for severe and treatment-resistant psychiatric disorders, particularly depression and catatonia. ECT requires intravenous (IV) access, which can pose a barrier for pediatric patients and those with neurodevelopmental disorders who may have difficulty tolerating IV placement. This case series highlights individualized...