Journal of NeurochemistryMay 1, 2026Jannik Nicklas Eliasen, Amir Rezagholizadeh, Helene Påbøl Jacobsen et al.
ABSTRACT Depression and substance use disorder (SUD) affect millions globally and unfortunately, while established treatments exist, they are not always adequate. Psychedelics have emerged as a promising avenue for development of more effective pharmacological interventions. Dimethyltryptamine (DMT), a classic psychedelic, has shown anti‐depressive and anti‐addictive properties in preclinical...
Research SquareApril 30, 2026Su-gyeong Lee, Jang-won Seo
preprint
Abstract Compassion is an emotional state experienced in response to witnessing the suffering of others, accompanied by an internal motivation to help. When directed toward the self, it is referred to as self-compassion. Previous research suggests that compassion and self-compassion are closely related to mindfulness and empathy, contributing to reductions in anxiety and depression and to the...
The increasing levels of anxiety, stress, academic burnout, and emotional dysregulation among students represent a significant global educational concern. Although Cognitive Behavioral Therapy (CBT) remains one of the most empirically validated methods for reducing anxiety and depressive symptoms in young populations, its application in educational settings often emphasizes immediate cognitive...
This paper introduces the concept of egostasis (self-based goal-directed persistence behaviour) and proposes a novel neurophenomenological theory of the experience of suffering, grounded in the framework of active inference. We argue that psychological suffering is a transmodal, aversive state arising from prediction errors being attributed to a self-model. Chronic suffering is proposed to...
This study conducted a meta-analysis to systematically evaluate the effectiveness of Buddhist meditation intervention programs on psychological health outcomes. A total of 138 studies published between 2024 and 2025, listed in KCI-indexed or KCI-candidate journals, involving 6,366 participants were analyzed. Effect sizes were computed using Hedges’ g under a random-effects model to account for...
Background and aims: Mindfulness-based relapse prevention (MBRP) has been shown to be beneficial to individuals with substance use disorder (SUD) in the West. The current pilot study aimed at testing the feasibility of MBRP in a Chinese population. Design: This pilot study adopted a design of randomized controlled trial comparing MBRP with treatment-as-usual group (TAU). Setting: Participants...
Depression is driven by dysfunction in discrete neural circuits, but a deeper understanding of the underlying molecular and synaptic mechanisms is needed to guide the development of therapeutics. Here, we decipher the mechanisms of action of the fast-acting antidepressant ketamine to enable the identification of G protein-coupled receptor (GPCR) antidepressant targets. We find that the...
BACKGROUND: Dementia affects over 50 million people worldwide, with numbers projected to triple by 2050. Informal caregivers-predominantly family members-provide the majority of daily care and exhibit disproportionately high rates of psychological distress, depressive symptoms, and perceived burden. Although mindfulness-based interventions (MBIs) have consistently demonstrated moderate-to-large...
Abstract Mental health disorders such as anxiety, depression, and stress-related conditions are increasing globally, posing significant challenges to healthcare systems. In recent years, there has been growing interest in complementary and alternative therapies, particularly yoga and meditation, as effective tools for mental health care. This research paper explores the role of yoga and...
Mental health issues are rapidly increasing in India and around the world. Depression, anxiety, stress, insomnia—these words no longer sound alien. But when it comes to treatment, most people think only of medications and psychiatrists. This is where yoga and meditation come into play—not just as a traditional practice, but also as a scientifically proven treatment method. This chapter attempts...