Recent retrospective analyses have shown that individuals with comorbid Substance Use Disorders (SUDs) are overrepresented among responders to ketamine for Treatment Resistant Depression (TRD). Ketamine is an effective treatment for depression and also a potential substance of misuse. The authors contrast a mechanistic pathway with a possible expectancy effect to account for these findings, and...
BACKGROUND: Hmong people experience a disproportionate burden of mental health challenges. While prior studies have examined mental health within Hmong communities, no study has focused on Hmong shamans’ experiences with depression. This study explores how Hmong shamans understand, experience, and respond to depression. METHODS: We conducted semi-structured, in-depth interviews with 12 Hmong...
This study aims to explore the effectiveness of implementing BAKU (Good and Strong) culture in Islamic mindfulness therapy as an alternative treatment for anxiety and depression among young Muslims, particularly in the Daarut Tauhiid Bandung environment. The background of this study is based on the high prevalence of mental health disorders, such as anxiety and depression, among Indonesian...
Background: Anhedonia and reward-processing deficits are core features of major depressive disorder (MDD) that respond poorly to traditional antidepressants.Ketamine has rapid antidepressant effects, yet its neurofunctional actions within reward circuits remain unclear.We synthesized human neuroimaging evidence on ketamine-related modulation of reward circuitry and implications for...
Upwards of 50% of people do not respond to the primary treatment modalities for major depressive disorder (MDD), which has led to increased attention and use of alternative methods, including exercise and psychedelics. While interventions using either exercise or psychedelics have demonstrated largely positive results in isolation, their synergistic potential has yet to be explored. As such,...
Intranasal esketamine represents a novel therapeutic option for Treatment-Resistant Depression (TRD). However, its medium-to-long-term risk-benefit profile in real-world clinical practice remains controversial. Limited data is available regarding its effectiveness, particularly in patients who have not responded to electroconvulsive therapy (ECT), which is the focus of this study. We conducted...
Treatment-resistant depression (TRD) accounts for approximately 30% of major depressive disorder cases and has been characterized by altered functional connectivity within and between the Default Mode (DMN) and Frontoparietal networks (FPN). Ketamine can be an effective treatment for TRD, and its antidepressant response has been associated with alterations in resting state functional...
Stress and HealthMarch 5, 2026A. G. Little, Matthew J. Stainer, Alex Sandy MacQuarrie et al.1 citation
Paramedicine students experience disproportionately high rates of anxiety, depression, stress, and insomnia compared to the general population, placing them at risk of post-traumatic stress disorder and long-term psychological distress. Breathwork has emerged as a promising self-regulation intervention that may enhance resilience and wellbeing while reducing symptoms of mental illness. This...
Approximately 30% of patients with depression suffer from treatment-resistant depression (TRD). Ketamine has shown antidepressant efficacy for TRD. While glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) has been demonstrated to play crucial roles in the process of pharmacological action of ketamine in experimental animals, it remains elusive how ketamine exhibits...
Introduction: This study examined the pathways linking mindfulness to emotion regulation and psychological symptoms among adults in Saudi Arabia. Methods: A total of 306 adults completed validated measures of mindfulness, emotion regulation (cognitive reappraisal and expressive suppression), depression, and anxiety. Structural equation modeling was used to test a hypothesized model in which...