PsychopharmacologyAugust 27, 2026Shayan Eghdami, Mahsa Boroon, Amir-Abbas Keshavarz-Akhlaghi et al.
Approximately 40-60% of patients with obsessive-compulsive disorder (OCD) fail to respond to standard serotonergic and behavioral therapies. This systematic review evaluates the efficacy, durability, and safety of ketamine, a glutamate modulator, for moderate to severe OCD. Following PRISMA guidelines, we searched electronic databases through January 2026 for studies treating moderate-to-severe...
Psilocybin, a psychoactive compound contained in certain mushrooms, can provoke profound psychedelic experiences and also exerts established and controversial therapeutic efficacy in clinical depression and other neuropsychiatric conditions respectively. Here we report that a single systemic administration of the serotonergic psychedelic psilocybin can durably promote social behaviour in the...
Abstract Introduction Oregon is the first US state to permit supervised psilocybin services through a nonmedical, wellness-based model. We examined what prospective clients with psychiatric histories encounter when contacting service centers, including how staff communicate about safety, eligibility, and cost. Methods We conducted a mystery shopper study of 26 licensed service centers in Oregon...
medRxivAugust 27, 2026Krista Whitley, Kai Davide Castellarin, Kumar Dave et al.
preprint
Abstract Ayahuasca use has expanded beyond its traditional Amazonian contexts, yet prospective longitudinal data examining depressive symptoms following naturalistic use in the United States remain limited. We conducted an interim analysis of an ongoing prospective observational cohort of adults participating in naturalistic ayahuasca use in Las Vegas, Nevada. Depressive symptoms were assessed...
Abstract Background Cannabis use has increased in recent years due to legalization. Smoking cannabis leads to inhalation of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD), in addition to other particles and gas in the smoke matrix as a result of combustion. The effect of THC on breathing pattern and metabolism has been characterized, but the influence of CBD and the smoke matrix on...
Objective: To evaluate changes in psychological distress, anxiety and depressive symptoms, sleep problems, and pain intensity associated with participation in an embedded micro-mindfulness program among patients with advanced cancer receiving palliative care, and to explore factors associated with psychological symptom response. Methods: This single-center, prospective, non-randomized...
This systematic review synthesizes evidence on the effects of meditation on physical and mental health in adults (ages 18 to 75) living with chronic physical health conditions. Meditation research in medical contexts has concentrated almost entirely on brief structured mindfulness programs such as MBSR and MBCT. Preliminary evidence from this literature indicates that mindfulness practice can...
This preregistration specifies the confirmatory efficacy and safety analyses for the main paper of the EX_WELL arm of the RESET Berlin trial. The trial compares circular breathwork against progressive muscle relaxation (PMR), an active, structurally matched comparator, in adults with trauma exposure and subclinical depressive symptomatology. The primary outcome is mental well-being (WEMWBS)....
August 26, 2026Mohammad Amin Wani, Vanshika Kohli, Sunita Dhenwal
Psoriasis is a chronic immune-mediated disease with major psychological, social, and quality-of-life consequences. This chapter critically reviews evidence on mindfulness-based cognitive therapy (MBCT) and related approaches in psoriasis care through a narrative analysis of psoriasis-specific studies, reviews, seminal sources, and policy documents. Findings suggest that MBCT may offer...