The International Journal of Neuropsychopharmacology
September 9, 2026
R Freire, C Chaves, M Cabo et al.
Abstract Background Anxiety disorders are among the most prevalent psychiatric disorders worldwide, causing significant impacts on physical and emotional health and substantial functional impairment. Not only individuals with anxiety disorders have severe and debilitating anxiety symptoms; patients with PTSD, OCD and mood disorders often present with anxiety. The term classic psychedelics...
The International Journal of Neuropsychopharmacology
September 9, 2026
J Ramaekers
Abstract Background Short-acting psychedelics such as 5-MeO-DMT and DMT may induce rapid relief of depressive symptoms after brief but intense psychedelic experiences. Aims & Objectives This presentation examines their clinical pharmacology and therapeutic potential in depression. Method Review of clinical data. Results Both compounds primarily target serotonergic receptors, notably 5-HT1A and...
Psychoanalytic Inquiry
September 8, 2026
Allen Kalpin
In recent years, researchers have demonstrated that the dissociative anesthetic ketamine provides therapeutic benefits for depression and other mental health problems, and when combined with psychotherapy, it is considered a type of psychedelic-assisted psychotherapy. In this article, I first review the main issues surrounding ketamine-assisted psychotherapy and then describe the psychodynamic...
The British Journal of Social Work
September 8, 2026
Alan Maddock, Talal Sultan M. Althobity, Karen McGuigan
Abstract Stress and burnout can have serious negative effects on individual social workers and the organizations they work for. Preliminary evaluations of the Mindfulness-Based Social Work and Self-Care (MBSWSC) programme have found that it reduces stress, burnout, depression, and anxiety and improves the mental well-being of social workers. Building on this evidence, the programme is currently...
Healthcare
September 8, 2026
Nafih Cherappurath, Halil İbrahim Ceylan, E. Anakha et al.
Background/Objectives: Mindfulness-based interventions (MBIs) have gained increasing attention in sport psychology due to their potential to enhance psychological well-being and performance-related outcomes among athletes. Despite various systematic reviews and meta-analyses examining mindfulness in athletic contexts, broader scoping evidence mapping randomised controlled trials (RCTs) of MBIs...
Zenodo (CERN European Organization for Nuclear Research)
September 7, 2026
Rebekka Waldesruh
preprint
This chapter examines one of the central misunderstandings surrounding the phenomenon traditionally referred to as the “Dark Night of the Soul”: its frequent reduction to clinical depression. Building on the introductory chapter, the present section develops a differentiated comparison between depressive states and the transformative process described in mystical traditions, particularly in the...
Molecules
September 7, 2026
Katarzyna Gawłowska, Katarzyna Kaja Nowakowska, Julia Wiktoria Makówka et al.
Standard pharmacotherapy for mental disorders, including depression and anxiety, is supported by extensive clinical validation and international treatment guidelines. However, it is frequently associated with limitations such as adverse side effects, low patient adherence, and the risk of relapse. Conventional approaches rely primarily on antidepressants, anxiolytics, mood stabilizers,...
Journal of Psychopharmacology
September 7, 2026
Sabrina Wong, Gia Han Le, Simryn Selby et al.
Extant literature indicates mitochondrial dysfunction may contribute to the pathophysiology of depressive disorders. Preclinical data indicate that anesthetic doses of ketamine are associated with deficits in mitochondrial viability and function. Ketamine and esketamine have demonstrated rapid antidepressant effects in persons with difficult-to-treat depressive disorders. Herein, we aim to...
Scientific Reports
September 5, 2026
Merrisa Lin, Nairán Ramírez‐Esparza, Natalie J. Shook
Despite experiencing more negative life events, older adults often report better emotional well-being than younger adults, a phenomenon known as the well-being paradox. Although socioemotional selectivity theory suggests that age-related shifts toward present-moment goals may contribute to this pattern, the psychological factors underlying these age differences remain unclear. In particular,...
September 5, 2026
Maurício Viotti Daker
BACKGROUND: The schizoidism-syntony dyad offers a good start for a comprehensive view of psychopathology. Rooted in schizophrenia and manic-depressive illness in Kretschmer's characterology, these concepts gained prominence, under Bleuler and Minkowski, as expressions of personal relational patterns to the environment. SUMMARY: It seems insightful, therefore, to compare the concepts to the...