International journal of toxicology
January 31, 2026
Amir Lotfi, Samantha Sparapani, Mylène Pouliot et al.
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a serotonin receptor agonist, in clinical development for the treatment of major depression and other psychiatric disorders. A critical safety concern for serotonergic compounds is their potential to induce seizures, as a severe manifestation of serotonin toxicity. The objective of this study was to evaluate the seizure liability of 5-MeO-DMT in a...
Journal of Psychiatric Research
January 29, 2026
Dandan Luo, Wenjun Dang, Jie Luo et al.
Individuals with autism spectrum disorder (ASD) and their caregivers often face challenges such as emotional distress and stress management, which severely impact their quality of life. Mindfulness-Based Stress Reduction (MBSR) holds potential value in emotional regulation; however, there is a lack of systematic evaluation targeting the ASD population, particularly caregivers. This systematic...
Quality in Sport
January 26, 2026
Adam Wolski, Ewa Szplit, Mikołaj Franciszek Patalong et al.
Background: Psychedelic substances have been used for millennia in religious and healing contexts and have recently re-emerged as subjects of scientific interest due to advances in neuroscience and psychiatry. Research suggests that psychedelics may address limitations of conventional psychiatric treatments, particularly in disorders such as major depressive disorder, PTSD, substance use...
Zenodo (CERN European Organization for Nuclear Research)
January 22, 2026
preprint
Psilocybin therapy shows potential benefits for mental health conditions such as depression and substance use disorders, though further research is needed to confirm long-term safety and efficacy.
Journal of Affective Disorders
January 19, 2026
Maria Garcia Garcia, Dahbia Belahda, Carine Graux et al.
Responders were distinguished by narratives of inner dialogue and adaptive coping, while non-responders emphasized sensory and affective descriptions and suppressive coping. Inner dialogue may constitute a distinct therapeutic mechanism, highlighting the importance of preparation and integration in psilocybin-assisted psychotherapy.
Brazilian Journal of Implantology and Health Sciences
January 15, 2026
Bianca Gasparotto da Silva, Giovana Labegaline Araújo, Bruna Rafaela Prestes et al.
Os transtornos depressivos representam uma das principais causas de incapacidade global, afetando de forma significativa o funcionamento emocional, social e ocupacional dos indivíduos. Apesar da ampla disponibilidade de antidepressivos convencionais, muitos pacientes apresentam resposta insuficiente ou efeitos adversos limitantes, especialmente aqueles com depressão resistente ao tratamento...
January 15, 2026
Benjamin Kelmendi, Thomas G. Adams, Terence H. W. Ching et al.
preprint
Background: Obsessive-compulsive disorder (OCD) affects 2-3% of the population worldwide. 40-60% of patients do not respond to first-line interventions. We evaluated the efficacy and safety of a single dose of psilocybin in patients with treatment-resistant OCD.Methods: In this phase 2, randomized, double-blind trial, we randomly assigned 28 adults with treatment-resistant OCD to receive a...
Journal of Psychopharmacology
January 13, 2026
James Glazer, Hanna Molla, Royce Lee et al.
Lysergic acid diethylamide (LSD) has been considered as a potential treatment for depression for over 75 years, but its therapeutic potential has only recently been considered in mainstream psychiatry. Repeated ingestion of low doses of LSD ("microdoses") is thought to reduce depression, but the neurobiology underlying this effect is unknown. We previously reported that low doses of LSD...
Diabetes, metabolic syndrome and obesity : targets and therapy
2026
Xiaoyan Xiu, Yingying Lin, Jiaying Lin et al.
Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with substantial maternal and fetal health risks. Apart from metabolic disturbances, a confirmed GDM diagnosis often elicits anxiety, depression, and diabetes-specific distress, which may activate the hypothalamic-pituitary-adrenal (HPA) axis, exacerbate insulin resistance, and undermine glycemic regulation,...
Frontiers in Oncology
2026
Jing Lei, Meimei He
Mindfulness-based stress reduction (MBSR) has shown promise in improving physical and mental health in breast cancer patients, warranting further comprehensive evaluation. This meta-analysis aimed to assess the effects of MBSR compared to usual care on the physical and psychological well-being of patients with breast cancer. A systematic search of Web of Science, PubMed, Cochrane Library, and...