Yuliya Knyahnytska, Reza Zomorrodi, Tyler S Kaster et al.
BACKGROUND Suicide is among the top 10 leading causes of death worldwide. Of people who died by suicide, the majority are diagnosed with depression. It is estimated that 25%-60% of people with bipolar depression (BD) will attempt suicide at least once, and 10%-15% will die by suicide. Several treatments, such as lithium, clozapine, electroconvulsive therapy, and cognitive behavioral therapy,...
Yun Du, Ruobing Feng, Wenle Zhang et al.
preprint
Abstract Background: The critical issue of treating Treatment-Resistant Depression (TRD) is to improve antidepressant effect rapid onset and the recovery rates. Significant antidepressant effects of ketamine onset rapidly, but decay rapidly and repeated dosing increases the risks. This study aimed to explore the efficacy and safety of single intravenous ketamine, combined with venlafaxines...
Danika Dai, Courtney Miller, Violeta Valdivia et al.
preprint
Abstract BackgroundKetamine has emerged as a rapid-acting antidepressant in treatment-resistant depression (TRD) increasingly used in non-research, clinical settings. Few studies, however, have examined neurocognitive effects of repeated racemic ketamine infusion treatments in patients with TRD. In an effort to identify potential effects after serial infusions, we conducted a retrospective...
Joseph C.W. Tham, André Do, Jason Fridfinnson et al.
preprint
Intravenous (IV) ketamine has been shown to have rapid antidepressant effects in individuals with treatment-resistant depression (TRD). This treatment protocol describes a clinical method for use of subcutaneous (SC) and intramuscular (IM) racemic ketamine in individuals with TRD, developed by a team at the University of British Columbia (UBC), UBC Hospital, and Vancouver General Hospital. The...
Minjung Kim, Jin Young Park, Sehwan Park et al.
BACKGROUND Pregnancy is a vulnerable period for women, exposing them to various mental health issues such as depression and anxiety. The perinatal period is particularly crucial because the mother's mental health significantly affects the mother’s physical health, pregnancy outcomes, fetal development, postnatal outcomes, and infant development. Psychotherapeutic approaches for depression are...
Jyoti Mishra, Dhakshin Ramanathan, Gillian Grennan et al.
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Abstract Interoceptive attention to internal sensory signals is fundamental to mindfulness. However, it is difficult to measure objectively, and the vast majority of investigations of the neural correlates of mindfulness-based attention rely on subjective and retrospective measures of distraction. In this study, we measured consistency of response times on a breath-monitoring task (instruction...
Catherine Malboeuf-Hurtubise, Geneviève Taylor, Terra Léger-Goodes et al.
preprint
Abstract The number of mindfulness-based interventions has proliferated in the last decade as accessible evidence-based practices to improve children’s mental health in schools. However, some studies also suggest that mindfulness programs do not have added values compared to other mental health promotion interventions. These differences in effectiveness can partly be due to the lack of...
Ravi Shankar, Anjali Bundele, Amartya Mukhopadhyay
BACKGROUND While traditional mindfulness-based interventions demonstrate effectiveness in improving mental health outcomes, their delivery methods face significant challenges related to accessibility and engagement. Geographic barriers to trained facilitators, time constraints for in-person sessions, and participant dropout rates of 15% to 30% due to perceived monotony limit intervention reach...
. Badil, Najma Naz, Dildar Muhammad et al.
preprint
Background and Objectives: Antenatal depression and perceived stress are prevalent mental health challenges in pregnant women, associated with male-child preference. The study aimed to assess the feasibility of a modified mindfulness training program on antenatal depression and perceived stress levels among expected mothers with male child preference at a public sector tertiary care hospital in...
Xuanyi Wang, Shulin Chen
preprint
AbstractBackground Youths are particularly susceptible to depression, as they face a critical but vulnerable phase of cognitive development. Cognitive interventions for youth depression are therefore warranted. Mindfulness, considered as the third wave of the cognitive revolution, shows great potential to address risk factors of depression, especially suppression and low self-esteem. Therefore,...