Jesús Isaac Castillo-Sánchez
preprint
Abstract The COMP006 Phase 3 trial showed that 39% of patients with treatment-resistant depression (TRD) respond to a single 25 mg dose of psilocybin, while 61% do not — at identical dose, protocol, and pharmacological exposure. No mechanistic explanation for this heterogeneity has been established. Here we propose and validate a two-threshold model in which the psilocybin dose-response...
Zeynep Yoldas, Willys Cantenys, Morgane Tronche et al.
preprint
Background: Facial emotion recognition deficits are well defined in depression but understudied in treatment-resistant depression (TRD). Over the past decades, subanesthetic doses of ketamine have emerged as an effective treatment for TRD, but its effect on affective processing is still little known. Approaches from computational psychiatry, such as sequential evidence sampling models of...
Ivy Shiming Huang, Yoyo Wing Yiu Cheung, Johan F. Hoorn
preprint
Depression often results in personal and social losses. Young people going through psychological changes are particularly vulnerable. This study explores the use of different treatments in reducing depression among young people and the possibility of using social robots as instructors in the process. Participants (N = 142), aged between 18 and 34 joined a one-time laboratory experiment. They...
Danielle Moskow Diamond, Joshua Curtiss, Joseph K. Carpenter et al.
preprint
Abstract Background: Many individuals who engage in mindfulness techniques experience decreased anxiety. Yet some who engage in mindfulness, particularly those with panic disorder (PD) or elevated anxiety sensitivity (AS) note heightened anxiety when focusing on particular sensations. The Five Facet Mindfulness Questionnaire (FFMQ) is the most widely utilized mindfulness questionnaire- however,...
Kenni Wojujutari Ajele, Erhabor Sunday Idemudia
Objective. This study evaluated the effectiveness of mindfulness-based interventions (MBIs) in managing comorbid depression and diabetes by assessing their efficacy in reducing depressive symptoms and improving glycemic control, while addressing inconsistencies in existing research.Research Design and Methods. A systematic review and meta-analysis were conducted of 17 randomized controlled...
Wawan Rismawan, Carla Raymondalexas Marchira, Ibrahim Rahmat et al.
preprint
Introduction: life expectancy is 67.4 years, while in 2020, it is predicted that the number of elderly people will be 28.8 million (11.34%) with a life expectancy of 71.1 years. The number of elderly in Tasikmalaya who more than 60 years old is 35,405 people, while those who are more than 70 years old are 18,581 people. There are 1,494 mental emotional disorders in all groups, no specific data...
Shadi Beshai
preprint
Objective: Individuals with a history of childhood maltreatment are particularly vulnerable to a longer course of depression. Immunization theories of resilience suggest that resilience and related factors may buffer against the deleterious effects of early childhood adversity. Trait mindfulness is linked to resilience and may be a pathway to cultivating this dynamic process. In this study, we...
Muhammad Abid Azam, Vered Latman, Joel Katz
Mindfulness-based interventions have received empirical support in recent decades for the management of symptoms related to depression, anxiety (Hofmann, Sawyer, Witt, & Oh, 2010) and chronic pain (Chiesa & Serretti, 2011). These interventions often provide training in mindfulness practices, including the introductory practice of mindful breathing which involves paying nonjudmental attention to...
Johannes Michalak, Maria Niemi, Maria Velana et al.
preprint
ABSTRACT Background Chronic and treatment-resistant depression remains a challenge. Although research has demonstrated positive effects of Mindfulness-Based Cognitive Therapy (MBCT) and Cognitive Behavioral Analysis System of Psychotherapy (CBASP), their potential negative effects—including deterioration, suicidality, and adverse events—are not well understood. Objectives This protocol outlines...
Nasrollahi Masumeh, Ghazanfar Pour Masumeh, Ahmadi Atefeh et al.
preprint
Abstract Background: Loss of a fetus may cause mental health problems in women. The aim of the study was to determine the effect of Mindfulness-Based on Stress Reduction (MBSR) on anxiety, depression, and stress of women with early pregnancy termination. Methods: This study was performed on 106 women with the early loss of pregnancy; in Shiraz, Iran. The intervention group underwent eight...