Philosophical transactions of the Royal Society of London. Series B, Biological sciences
July 23, 2012
Ronald S. Duman, Nanxin Li
361 citations
Molecular and cellular studies have demonstrated opposing actions of stress and antidepressant treatment on the expression of neurotrophic factors, particularly brain-derived neurotrophic factor, in limbic structures of the brain. These changes in neurotrophic factor expression and function result in structural alterations, including regulation of neurogenesis, dendrite length and spine density...
Journal of Psychiatric Practice
July 1, 2012
William R. Marchand
309 citations
Mindfulness has been described as a practice of learning to focus attention on moment-bymoment experience with an attitude of curiosity, openness, and acceptance. Mindfulness practices have become increasingly popular as complementary therapeutic strategies for a variety of medical and psychiatric conditions. This paper provides an overview of three mindfulness interventions that have...
Journal of Clinical Psychopharmacology
June 20, 2012
Lobna Ibrahim, Nancy Diazgranados, Libby Jolkovsky et al.
219 citations
Converging lines of evidence suggest that the glutamatergic system may play an increasingly important role in the development of novel therapeutics for major depressive disorder (MDD), particularly agents associated with rapid antidepressant effects. Diverse glutamatergic modulators targeting N-methyl-D-aspartate receptors have shown efficacy in MDD, but their associated psychotomimetic effects...
Social Cognitive and Affective Neuroscience
June 19, 2012
Natalie A Paul, Steven J Stanton, Jeffrey M Greeson et al.
Mindfulness-based interventions are effective for reducing depressive symptoms. However, the psychological and neural mechanisms are unclear. This study examined which facets of trait mindfulness offer protection against negative bias and rumination, which are key risk factors for depression. Nineteen male volunteers completed a 2-day functional magnetic resonance imaging study. One day...
The International Journal of Neuropsychopharmacology
June 7, 2012
Wallace C. Duncan, Simone Sarasso, Fabio Ferrarelli et al.
253 citations
The N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has rapid antidepressant effects in treatment-resistant major depressive disorder (MDD). In rats, ketamine selectively increased electroencephalogram (EEG) slow wave activity (SWA) during non-rapid eye movement (REM) sleep and altered central brain-derived neurotrophic factor (BDNF) expression. Taken together, these findings suggest...
Journal of Contemporary Psychotherapy
June 1, 2012
Lloyd Lalande, Matthew Bambling, Robert A. King et al.
Breathwork is an increasingly popular experiential approach to psychotherapy based on the use of a specific breathing technique, however, claims of positive mental health outcomes rely on anecdotal clinical evidence. To ascertain the likely efficacy of breathwork this review clarifies the approach and its theoretical assumptions and examines relevant empirical research relating to breathing...
Behaviour Research and Therapy
May 30, 2012
Johanna Thünker, Reinhard Pietrowsky
Nightmares are a common and serious problem in psychotherapeutic practice, although they are seldom considered as independent mental disorders. There are some promising approaches to the treatment of nightmares, notably Imagery Rehearsal Therapy, a cognitive-restructuring treatment. The core of this approach is the modification of the nightmare script and repeated imagination of the new script....
Behavioural and Cognitive Psychotherapy
March 1, 2012
Vijaya Manicavasagar, Tania Perich, Gordon Parker
Background: An appreciation of cognitive predictors of change in treatment outcome may help to better understand differential treatment outcomes. The aim of this study was to examine how rumination and mindfulness impact on treatment outcome in two group-based interventions for non-melancholic depression: Cognitive Behaviour Therapy (CBT) and Mindfulness-Based Cognitive Therapy (MBCT). Method:...
British Journal of Clinical Pharmacology
February 1, 2012
Xiaochen Zhao, Swarajya Lakshmi Vattem Venkata, Ruin Moaddel et al.
136 citations
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • (R,S)‐ketamine is a phencyclidine derivative that was initially developed as an anaesthetic agent and which is currently being studied in the treatment of pain and depression. After administration, the drug is extensively N‐demethylated to (R,S)‐norketamine. The pharmacokinetics of ketamine and norketamine have been extensively studied in volunteers...
Advances in Consciousness Research
January 25, 2012
Johannes Michalak, Jan M. Burg, Thomas Heidenreich
During the past decade, Mindfulness-Based Cognitive Therapy (MBCT) aiming at relapse prevention in depression has been developed and empirically tested. All exercises taught during MBCT are based on the development of a heightened awareness of one’s body. The important role of the body is also stressed in a recently emerging interdisciplinary field of research termed ‘embodiment’. This research...