Mindfulness
January 12, 2017
Marloes J. Huijbers, R. Crane, Willem Kuyken et al.
As mindfulness-based cognitive therapy (MBCT) becomes an increasingly mainstream approach for recurrent depression, there is a growing need for practitioners who are able to teach MBCT. The requirements for being competent as a mindfulness-based teacher include personal meditation practice and at least a year of additional professional training. This study is the first to investigate the...
Journal of Neuroscience Research
January 2, 2017
Tracey J. Shors, Emma M. Millon, Han Yan M Chang et al.
It is generally accepted that women tend to ruminate more than men do and these thought patterns are often associated with depressive symptoms (Nolen-Hoeksema et al., ). Based on these findings, we considered whether the relationship between rumination and depression is stronger in women than in men and if so, whether this might explain the higher prevalence of major depressive disorder (MDD)...
Princeton Journal of Pre-Collegiate Research
2017
Ariel N. Shapiro, James T. McAllister, Priya V. Nair
This study investigates antidepressant onset kinetics, AMPA/NMDA ratio biomarker response prediction, and 14-day depression score durability following a single sub-anesthetic ketamine infusion in treatment-resistant major depression within the context of neuropsychopharmacology and clinical psychiatry, an area of growing scientific importance given its implications for treatment-resistant...
CNS & Neurological Disorders - Drug Targets
2017
Gustavo Vazquez, Sebastian Camino, Leonardo Tondo et al.
Treatments for depression in bipolar disorder (BD) are far less well developed than for unipolar major depressive disorder. Several innovative and experimental approaches have been emerging recently, including use of the dissociative anesthetic ketamine and other antagonists of central NMDA glutamate receptors, as well as unsaturated fatty acids, anti-inflammatory agents, and possibly probiotic...
Journal of Psychiatric Research
January 2017
Minkyung Park, Laura E Newman, Philip W Gold et al.
Several pro-inflammatory cytokines have been implicated in depression and in antidepressant response. This exploratory analysis assessed: 1) the extent to which baseline cytokine levels predicted positive antidepressant response to ketamine; 2) whether ketamine responders experienced acute changes in cytokine levels not observed in non-responders; and 3) whether ketamine lowered levels of...
Mental Health Clinician
January 2017
Sarah E Grady, Travis A Marsh, Allison Tenhouse et al.
Over the past decade, ketamine has been studied for major depressive disorder and bipolar depression. Ketamine is believed to exert its antidepressant properties through N-methyl-D-aspartate receptor antagonism. Study authors completed a literature review of seven randomized controlled trials of ketamine usage in major depressive disorder and bipolar depression. Ketamine demonstrated a...
Neural Plasticity
2017
Yu-Jhen Huang, Hsien-Yuan Lane, Chieh-Hsin Lin
77 citations
Major depressive disorder is a severe and complex mental disorder. Impaired neurotransmission and disrupted signalling pathways may influence neuroplasticity, which is involved in the brain dysfunction in depression. Traditional neurobiological theories of depression, such as monoamine hypothesis, cannot fully explain the whole picture of depressive disorders. In this review, we discussed new...
The Journal of Clinical Psychiatry
2017
Anup Sharma, M. Barrett, A. Cucchiara et al.
Objective To evaluate feasibility, efficacy and tolerability of Sudarshan Kriya yoga (SKY) as an adjunctive intervention in patients with major depressive disorder (MDD) with inadequate response to antidepressant treatment. Method Patients with MDD (defined by DSM-IV-TR) depressed despite ≥8 weeks of antidepressant treatment were randomized to SKY or a waitlist control (delayed yoga) arm for 8...
Clinical pharmacist
2017
Psilocybin, a psychoactive component of magic mushrooms, is thought to have therapeutic potential in psychiatric disorders but its mechanism of action within the brain is unclear. In a study, researchers gave two doses of psilocybin to 19 patients with treatment-resistant depression, and studied blood flow within the brain using functional magnetic resonance imaging (MRI) at […]
Psychotherapy and Psychosomatics
2017
Samuel T. Wilkinson, Dashaun Wright, Madonna K. Fasula et al.
120 citations
<b><i>Introduction:</i></b> Ketamine has shown rapid though short-lived antidepressant effects. The possibility of concerning neurobiological changes following repeated exposure to the drug motivates the development of strategies that obviate or minimize the need for longer-term treatment with ketamine. In this open-label trial, we investigated whether cognitive behavioral therapy (CBT) can...