This paper explores whether some religious and spiritual experiences (RSEs) associated with depression resemble hypomania/mania. Content analysis and phenomenological analysis were used to characterize first-person RSE reports associated with depression (N = 249). Findings reveal that some RSEs that follow depression are characterized by long-duration states (lasting days to weeks) of positive...
Summary Nitrous oxide is being investigated as a treatment for therapy-resistant depression, yet its environmental implications as a potent greenhouse gas are largely unaddressed. A single 1 h treatment generates ∼150 kg CO 2 -equivalents, rising to ∼7.8 t per patient-year, highlighting the need to incorporate environmental externalities into evaluation.
Pharmacological treatment for postpartum depression (PPD) have mainly involved conventional antidepressants, RCTs have also evaluated rapid-acting glutamatergic agents, neuroactive steroids, hormonal therapies, and botanical preparations. An updated comparative synthesis of these treatments is therefore needed. To synthesize RCT evidence and compare the efficacy, response, remission,...
Patients with treatment‐resistant depression who received psilocybin‐assisted psychotherapy showed clinically meaningful improvement in depressive symptoms relative to placebo, a Phase 2b trial has found. However, the study did not show a significant effect on the primary outcome of treatment response 6 weeks after the first of two doses of psilocybin. Study results were published online March...
Introduction Treatment-resistant major depressive disorder with high-risk suicidal ideation is a psychiatric emergency that requires rapid and effective intervention. Although intranasal esketamine and intermittent theta-burst stimulation (iTBS) are time-efficient therapeutic options, clinical reports describing their combined use in an accelerated inpatient schedule are limited, particularly...
Treatment-resistant depression (TRD) represents an unmet challenge, accounting for disproportionate morbidity, disability, and healthcare burden in depression. Limitations of monoaminergic antidepressants have prompted a conceptual shift toward models emphasizing impaired neuroplasticity, synaptic dysfunction, and network dysregulation. This expert review synthesizes preclinical, translational,...
Background and Objective Ketamine and esketamine have emerged as effective and rapid-acting interventions for treatment-resistant depression. Nevertheless, the best-suited candidates for these treatments are not clear. As such, the ability to personalize treatment selection and parameters would likely improve therapeutic response. This systematic review synthesized the literature on clinical...
Purpose: This study investigated the mediating roles of mindfulness and anxiety in the association between pregnancy stress and depression among hospitalized women with high-risk pregnancies. Methods: Employing a cross-sectional descriptive design, this study was guided by the Transactional Model of Stress and Coping. Data were collected from 109 high-risk pregnant women admitted to a...
IJNPJune 30, 2026Nurul Azizah, Rafhani Rosyidah, Widi Arti
Background: Postpartum women are vulnerable to pain and psychological disturbances such as stress, anxiety, and depression, which may affect maternal well-being and infant care. Mindfulness-Based Stress Reduction (MBSR) is a promising non-pharmacological intervention to enhance postpartum recovery. Objective: This study aimed to evaluate the effectiveness of MBSR in improving pain tolerance and...
BACKGROUND Anxiety and depression are prevalent and often co-occurring mental health disorders. While mindfulness training has shown efficacy in reducing symptoms, the underlying mechanisms, particularly the role of psychological resilience, remain underexplored. This study investigates whether mindfulness training alleviates anxiety and depression and hypothesizes that psychological resilience...