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Journal of Clinical Psychopharmacology July 28, 2026
Hepatic Safety of Ketamine and Esketamine for Treatment-Resistant Depression: A Real-World Cohort Study.
Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal July 28, 2026 Danial O. Beniameen, Armya O. Beniameen
Background: Major depressive disorder (MDD) affects over 280 million people globally and remains a leading cause of disability. Psilocybin has emerged as a promising treatment, with evidence suggesting modulation of neural oscillatory activity relevant to mood regulation. Electroencephalography (EEG) and magnetoencephalography (MEG) offer non-invasive methods for evaluating these...
npj Mental Health Research July 27, 2026 Jennifer Swainson, P. Grewal, S. Polard et al.
This scoping review maps literature for use of ketamine or esketamine with psychotherapy for depression or depressive symptoms. Forty-seven studies were identified including 4/47 (9%) randomized controlled trials, 4/47 (9%) open label trials, 27/47 (57%) observational or retrospective studies, and 12/47 (26%) individual case reports. Studies were categorized as Ketamine/Esketamine Combined with...
McMaster University Medical Journal July 26, 2026 Annie Xiong, Sebastian Kolde, Paul S. Links
Background: Pharmacologic treatment options for borderline personality disorder (BPD) remain limited, and no medication has received regulatory approval for its treatment. Given the high rates of comorbid depression and suicidal ideation in BPD, there is growing interest in novel therapeutic approaches. Ketamine has been approved for treatment-resistant depression and acute suicidality, raising...
Journal of Affective Disorders July 23, 2026
Rapid clinical and EEG microstate changes 24 h after intranasal esketamine in major depressive disorder with suicidal ideation: a prospective paired study.
Mindfulness July 22, 2026 Kate Gliske, Gretchen Buchanan, Delaina Carlson et al.
Maternal mental health during pregnancy and the postpartum period is critical for offspring’s well-being. Mindfulness-based programs (MBPs) are evidence-based approaches that reduce psychological distress such as depression, anxiety, and stress while promoting well-being. MBPs may be particularly suited to the perinatal period, given concerns about psychotropic medication use during pregnancy...
Current Neuropharmacology July 22, 2026
Esketamine in Treatment-Resistant Depression: Clinical and Translational Perspectives.
European Neuropsychopharmacology July 17, 2026 Allan H. Young, Bernhard T Baune, Beatrice Benatti et al.
Esketamine nasal spray (NS) is an established treatment for patients with treatment resistant depression (TRD). To further optimise real-world outcomes, consensus is needed regarding strategies to enhance patient outcomes and decision-making factors for pivotal timepoints in esketamine NS treatment. This modified Delphi panel (3 rounds) established expert consensus (≥80% agreement) from 30...
Zenodo (CERN European Organization for Nuclear Research) July 17, 2026 Bartosz Niciński, Magdalena Kloc, Ewa Wiench, Natasza Millan, Aleksandra Blicharz, Wojciech Kozdraś, Lidia Kozaczko, Gabriela Szewczyk, Elżbieta Bukowczan, Alicja Zając, Damian Broda, Alicja Benecka preprint
Major depressive disorder is a highly burdensome psychiatric condition worldwide, and many patients do not achieve full remission after standard monoaminergic antidepressant treatment. This has contributed to growing interest in rapid-acting antidepressant interventionstargeting neurobiological pathways beyond traditional serotonin, norepinephrine, and dopamine mechanisms. This review...
July 16, 2026 Dan Degerman
This chapter returns to depression to examine rumination in light of the capacity to be inwardly silent. Rumination is typically defined as repetitive and persistent negative thinking, yet its experiential structure has received limited phenomenological attention. Building on the framework developed earlier in the book, the chapter argues that many cases of rumination involve a disruption in...