Background: Treatment-resistant Depression (TRD) does not respond to conventional treatments. Despite the efforts made to control depression, the outcomes are controversial and inconclusive. New strategies such as ketamine use are accompanied by promising outcomes; however, the best dosage remains a question. Objectives: The current study aimed to compare the effect of 1 and 2 mg/kg of oral...
It has been demonstrated that one of the components of mindfulness meditation, called self-kindness, plays a prominent role in alleviating distress perception, and reducing depressive symptoms, especially among younger women with breast cancer (BC), who represent a particularly vulnerable patient population, often struggling not only with a serious illness but also with numerous family and...
Several recent studies have investigated psilocybin as a novel therapeutic compound for the treatment of existential distress in patients with cancer, demonstrating persistent, positive effects on mood. This editorial discusses two articles in the current issue of Cancer that report findings of a group‐based psilocybin‐assisted intervention for treatment of depression in patients diagnosed with...
Abstract Background The present study explored the acceptability of psilocybin‐assisted group therapy from the perspective of patients with cancer and depression who participated in a clinical trial assessing the safety and efficacy of this novel intervention. Methods Guided by the conceptual framework of acceptability, the authors conducted semi‐structured interviews with participants of the...
Abstract Background Depression is common in patients with cancer and is associated with lower treatment adherence and reduced quality of life. Antidepressants and psychotherapy have limited success in improving depression among patients with cancer. This study explored the safety, feasibility, and efficacy of psilocybin‐assisted therapy in patients with cancer and major depressive disorder....
Abstract Interest in psychedelics is increasing due to potential for improved mental health and quality of life. However, adverse effects on mental health are still a concern. Personality traits have been suggested to both influence the psychedelic experience and mental health, and even be changed by psychedelic use. The present study describes for the first time a national sample of Swedish...
Bipolar depression constitutes a major problem in psychiatry. It correlates with high suicidality, treatment resistance, chronicity, and poor quality of life. Registered treatment for bipolar depression is limited and insufficient. There is an urgent need for implementing new therapeutic strategies. Intranasal ketamine’s enantiomer—esketamine is a novel rapid-acting antidepressant with proven...
Abstract Depression is a reason of the most common causes of premature death. Therefore, it becomes crucial, to find simple preventive measures. Many research show that the combination of pharmacotherapy and mind-body interventions is an effective way. The purpose of the pilot study is to analyze the potential use of an active form of meditation for prevention and alleviation of depressive...
Nitrous oxide (N2O – also known as Hilarious Gas) has recently emerged has a potential fast-acting antidepressant, based on a number of randomized controlled trials (RCT) in young adults with treatment resistant depression (TRD). The antidepressant mechanisms of N2O are not fully understood but may include an antagonist action on NDMA receptors, similar to ketamine. N2O shows additional...